Today is the summer solstice and that is why this blog is being released today. More people with bipolar disorder will be admitted to ERs in the Northern Hemisphere today than any other day.  Now you are going to learn why this is the case.

Bipolar disorder (BD) is a chronic and common psychiatric pathology, which can be particularly disabling. The disease has a global prevalence rate of 1–4%, begins at an early age, i.e. predominantly between 15 and 25 years old, and persists throughout the life of patients. BD is characterized by a recurrence of mood depressive episodes (pathological decrease in mood and energy), hypomanic or manic episodes (pathological increase in mood and energy), or even mixed episodes (simultaneous presence of depressive and manic symptoms).

Bipolar disorder is a common mental condition in our modern world with a seasonal pattern of onset. In the spring, there is a higher incidence rate of mania or mixed onset and suicide associated with the equinox and solstice.  The reason for this is a defective pruning mechanism related to the cortisol melatonin cycle in cells.  The question is then what controls this pruning in us?

LINK

The pruning method of control in the brain is normally controlled by the cortisol melatonin cycle.  Cortisol usually creates new pathways and melatonin trims or prunes them to suit the environment the person is in.

In bipolar disorder, this system has gone awry.  Remember cortisol is controlled by light via ACTH and melatonin levels are made by the mitochondrial matrix.

Explain this to me like I am a 3rd grader Uncle Jack.

What if I told you it was because the FM radio station evolution built into your head went awry because the manner in which it works was usurped by your light choices? Would you believe that?

The FM receiver used by Mother Nature in our brain includes a clock that measures light and cavities filled with water. It turns out that the shape of things in our heads is prognostic on how good time our clocks tell. Imagine that. These two antennas use a phase-locked loop system that is also used in modern FM radio receivers in our car. Can you believe that? Because of its usefulness, the phase-locked loop is found in many wireless, radio, and general electronic items from mobile phones to broadcast radios, televisions to Wi-Fi routers, walkie-talkie radios to professional communications systems, and very much more.

Mother Nature built this FM radio station in the nervous system over 3 billion years ago. This is why brains first became important. Their original purpose was to inform cells of the seasonal connection between the sun and Earth. In turn, this data could be made useful to direct biological changes. This is how light changes the biochemistry inside of us. This is how we know it is summertime. In bipolar disorder, this system is awry when it is encumbered by too much mass in the antennae of the system.

What bends space/time in the universe? The masses associated with the matter in the universe do. Anything that has more mass than the smallest atom used inside of our molecular clocks changes how we experience time. Mass bends space/time!  Now ask yourself what magnetic fields do to space-time based on this picture below.

Magnetic fields tend to flatten and stiffen the fabric of space-time when masses are added to them and this alters our perception of seasons.

The circadian activity generated in the SCN clock of the eye needs to be transmitted to the rest of the brain in some way. It seems like the clock timing tract splits into two wires and informs the brain of what season it is. In Bipolar Disorder this is impossible because the eye clock is usually where the defect lies.  That defect in the antenna ruins the fidelity of the system and our brain cannot tell where the Earth and sun are in relation to one another. Pretty remarkable gadget Nature built in our heads. It appears the excess mass in the antenna screws up the connection of the FM radio station. Without a proper connection, the fidelity of the music coming from the system fails. That is what bipolar disease is to a metronome. Can you believe that? My friend the metronome says it's all true because of the physics of clock timing. It is apparently thrown off when we have too much weight (mass) in our clocks. Does something to the fabric of space-time deform magnetic fields? Wild decentralized stuff I tell you.

The 3rd-grade bipolar lesson is over.

BACK TO THE SCIENTIFIC EXPLANATION OF BIPOLAR DISEASE

These thymic episodes the bipolar patient experiences are interspersed with phases of clinical remission, known as “euthymic” episodes. The disease is associated with a high morbidity and mortality rate and due to the significant functional impact it induces, including during euthymic periods, BD is the cause of poor quality of life and is one of the ten most disabling diseases according to the World Health Organization. The diagnosis of BD is mainly clinical and can be supported using scales or questionnaires. The diagnostic delay is estimated at around 10 years. This delay is clearly related to the heterogeneity of the clinical expression of the disease. The phenotype of the disease is relative because how patients experience time is relative to the environment they inhabit.

The study of the literature shows that this delay in treatment seriously affects the prognosis, particularly on the functional level, and constitutes a major public health problem. In addition, there are no good biomarkers, easily usable in current practice, to help the clinical decision for the diagnosis or for predicting the course or prognosis of the disease.  One thing is known about bipolar people.  Many of them have the same changes in their eye as diabetics.  They also tend to get metabolic syndrome in the guts more frequently than any other mental illness as is documented in the cites below. They tend to have pale skin in their thoracic and lumbar regions as well.

WHY ARE SLEEP DISORDERS ALWAYS LINKED TO THIS DISEASE?

Sleep disturbances and sleep/wake rhythms are major in BD. These disturbances are observed during the different phases of the disease and are major symptoms of mood episodes and belong to the diagnostic criteria for depression, hypomania, and mania. In addition, these anomalies are also found during the euthymic phases of this disease. Indeed, patients suffering from BD would be more likely to present a more evening chronotype and a more languid and rigid circadian type than healthy subjects as well as a decrease in the efficiency of their sleep, an increase in sleep duration, an increased sleep latency and a prolongation of the duration of awakenings after the onset of sleep. These disturbances in sleep and wake/sleep rhythms are associated, among other things, with more frequent relapses, an alteration in the quality of life, and cognitive disorders.

Additionally, neurocognitive deficits are frequently associated with BD. Most typical deteriorations found are impairment of episodic verbal memory, executive functions, processing speed, and sustained attention. These troubles can be present during mood episodes but also in around 30% of patients during euthymic phases. Cognitive deficits of patients with BD have a direct impact on their psychosocial functioning, on the risk of relapse, on treatment adherence, or even on their ability to insight. Their early detection associated with the identification of prognostic and predictive biomarkers of the response to cognitive and functional remediation tools is essential in order to be able to offer early and appropriate treatment.

Due to its embryological origin, the retina is an integral part of the central nervous system. The retina is a complex neural tissue (above in a BD patient), consisting of several layers of retinal neurons. They have structural and functional properties similar to cerebral neurons.  You've seen this laid out in detail in this series.  In addition, molecules involved in brain neurotransmission such as dopamine, serotonin, glutamate, or GABA, are also involved in retinal neurotransmission. The retina is now considered a relevant candidate for the study of neurotransmission abnormalities in neuropsychiatric pathologies. The function of retinal neurons can be measured using the OCT (below) or the electroretinogram (ERG).

ERG is a simple, fast, inexpensive, and non-invasive process that aims to measure the electrical activity of retinal neurons in response to light stimulation and provides indicators of synaptic transmission. This technique can represent an important electrophysiological measurement in biomarker research within psychiatric diseases. However, studies evaluating retinal function with ERG in BD are very few today.  I think in the future  In addition to the electrophysiological anomalies mentioned above, structural anomalies at the retinal level have been described. Indeed, several studies carried out in optical coherence tomography (OCT) have shown that subjects with BD present a thinning of the layers of retinal neurons. Additionally, results also seem to suggest that retinal thinning in the periphery of the retina where melanopsin is located may be related to disease progression.  People with bipolar disease are exquisitely sensitive to light at night it appears.  This is what makes them different.

As previously described elsewhere on Patreon, retinal neurons and cortical neurons have similar properties. It should be noted that measurements of retinal function with ERG and measurements of cortical function with visual evoked potentials (VEP) share the same characteristics. Indeed, both can be performed using light flash stimulation and using luminous black-and-white reversing checkerboard (pattern stimulation). In addition, they are complementary measures for the analysis of dysfunctions of the central visual pathways. Thus, the combined study of VEP using EEG could be relevant and complementary to ERG for a study of all visual neural pathways in neuropsychiatric pathologies in the future.  I think OCT shows these changes when clinicians think to order them in bipolar patients.  This is going to be how centralized medicine slowly decentralizes in my opinion as these tests reveal the quantum mechanical changes that occur in the antennae of the phased loop signaling you are about to learn about in this blog.

BIPOLAR DISEASES AND LITHIUM & METABOLIC SYNDROME

Lithium is the most common drug used to treat bipolar disorder.  Overall, compared to a placebo, lithium appears to decrease the risk of suicide by more than 60% in bipolar disorder.

Blue light increases blood glucose and insulin from POMC cleavage of ACTH and CLIP.  Did you know that people with newly diagnosed bipolar disorder are 3.5 times more likely to have metabolic syndrome? What is the connection?  Abnormal light in their night environment is the link.  Metabolic syndrome changes how the gut works with the brain because of changes in the SCN and the CSF that surrounds the thalamus.  It is most often seen in those who live an indoor existence while bathing themselves in blue light and nnEMF.  

The best way to avoid all mental illness is to remain in the sun and remain in the dark when the sun sets.   It is not that hard when you understand how light changes the topology of the eye, skin, and gut.  When you bathe in light at night or day mental illness and a sleep disorder will find you eventually in some way.

ISOTOPIC LESSON ON LITHIUM:  DEEP PHYSICS

Lithium drugs are widely used for treating bipolar disorder. They work, but nobody really knows how they work in cells. I think I might. How might a mitochondriac attack this problem? How about by mito-hacking the periodic table of elements yet again?

Consider the link between size discrepancy and the proton spin crisis between B-meson and protons. B-mesons are approximately 2/3 the size of protons and each of the quarks that make them up have a spin of 1/2. Protons do not follow the expected spin predictions that mesons have given us. Why would lithium be linked to this proton story? Remember that mitochondria in neurons deal with protons and B-mesons in the mitochondrial matrix as I laid out in my April 2016 webinar on this topic.  Those details are not important here but the size difference of the atoms is.

Might lithium's effects somehow be due to the quantum effects of the size variation of isotopes found in the matrix in the SCN and the leptin-melanocortin pathways in some areas as it travels through the brain?

You do know that different isotopes of elements have different nuclear spins, right?  People who listened to my Kruse for Dummies lecture should now fully understand why lithium works in bipolar disorder and why it can help reverse some of their Metabolic syndrome effects. Lithium alters the binary code of life because it has a spin number that mimics one of the atoms used in the binary code of biology.

Guess why a mitochondrion favors protium (H+) over deuterium (D)?  Atomic mass is the answer.

Might isotopic effects cause some quantum change in a material or a receiver built into our system? Might the size variation of isotopes found in the blood be linked by Nature to make circulating blood act differently than water in other parts of our body?   LINK TO THE LECTURE

IS BIPOLAR DISEASE REALLY AN ALTERED SIMULATION OF REALITY DUE TO ISOTOPE VARIATION IN NEURONS?

Deuterium is an isotope with spin = 1, unlike hydrogen-1, which has spin = 1/2.

Photons (particles of light) can have a spin of –1 or +1.

Why can't photons have 0 spins?

The definition of the spin as the angular momentum of a particle at rest is also inapplicable to the photon since there is no rest frame for the photon, which moves at the speed of light. Light never rests or stands still once it is liberated from matter.

What bends space/time? Mass does. Since Deuterium has more mass than H+ it bends space/time more than protium. Now ask yourself what magnetic fields do to space-time.  Any guess?  

By reanalyzing the basic equations of general relativity, a researcher has discovered that magnetic fields tend to flatten and stiffen the fabric of space-time when masses are added to them.

How does this affect the wireless magnetic circuits between the sun, earth, and the human brain?

It should immediately raise a question in your mind.  What is it about this solar circuit in bipolar patients, that makes the daytime powerful for them?  Daytime has strong electric fields associated with solar light.  Nighttime has little charge available.

Does a strong electric field cause time dilation in the SCN and the tracts linked to it in the mammalian brain?  What does that light do to water filled with deuterium in the bipolar brain? 

It appears you need a ton of sunlight to offset this effect.  What if you live at a high latitude?  Will that help this disease?  Nope.  Why?  Physics holds the answer.

The spacetime curvature for a charged static spherical body is given by the Reissner–Nordström metric:

With these mathematics, you can feed in the value of whatever charge you want and calculate the time dilation as a function of distance from the charged body. If you do this you'll discover something rather odd in Einstein's field equations, namely, the charge reverses the effect of the mass in them.

How do cells increase their charge?  

LIGHT DOES IT

Do you remember how many times I have told you in podcasts that redox potential is formed by adding net negative charges in a cell?  Do you see now how that charge can offset the bad isotopic variation in some of your tissues to make your clocks work better in the circuit that tells the brain what season it is?  This is another universal law not subject to an RCT.  

Remember sunlight deuterium depletes our tissues in many ways.  Light at night adds massive, via deuterium to our tissues and the water networks in our brain. This is how mass is added to human tissues.  The more mass added means the more sunlight you need to raise the charge to offset your light addiction at night.  How do you do this?  Your cells need to create light so you can create melanin & water from POMC and mitochondria respectively, to add charge to your tissues.  This energy then can be absorbed and stored at the vibrational levels in cells for later use.  Without that charge, our SCN & molecular clock function is degraded.  Degrade clocks = poor periodicity.  All of these are OLD LESSONS FROM OLD BLOGS FOR YOU NOW.

Is this why mammals conserve charge using their POMC biology in their cells Uncle Jack to offset this deuterium problem?  Yep.  The excess mass of heavier isotopes in cells and mitochondria causes time to slow (relative to the observer at infinity) but adding charges back to proteins/water (of either sign) can make the time speed up again.

Wait a minute Dr. Kruse, explain that again like I am a 3rd grader.

The sun creates massive electric fields during daylight. Implications for Bipolar Disorder?

Does a strong electric field cause time dilation in the universe?  Yes, it does because a strong electric field generated by the sun adds a massive net negative charge to cells that absorb this radiation.  POMC makes sure this happens in the human brain via Noether's theorem.

This is true because the mathematics of physics says it operates this way.

It appears this is what really causes Bipolar disorder at its fundamental core.

TYING IT BACK TO MY THESIS OF THIS SERIES: POMC

The adrenal medulla of mammals was born under the light stress of the KT event. This is why I wrote the adrenal fatigue blog years ago but no one saw things back then like they do now. I told the implications of that Huberman/Rubin podcast were VAST.  Bipolar disorder is one of these VAST effects.

Man's five senses can capture the vastness and the immensity of our cosmos and POMC is the paintbrush that allows it. POMC is the paint that goes on the canvas, your brain. POMC is a color palate that humans use to paint their minds. In some ways, that palate confines us to the limited real estate of the sensory organs in our brains to understand all the complexity of the universe. All 5 senses tract directly to the thalamus of humans which surrounds the 3rd ventricle of their brains.  But there is wisdom in being connected to nature in this fashion. Yet, few see the artistic symmetry of confinement. I am trying to explain this art to you now every day, in every word I write in every one of these blogs.  It is time for you to LEVER UP your knowledge.

THE LEVER-UP LESSON:  The adrenal cortex synthesizes three main groups of hormones (glucocorticoids, mineralocorticoids, and adrenal androgens) (Auchus and Miller, 2001). The homeostasis of glucocorticoids is regulated by a feedback mechanism CONTROLLED BY POMC gene translation via solar light and temperature sensors (non-visual photoreceptors) in the skin, eye, and autonomic nervous systems that are relayed to and through the hypothalamic POMC centers in many neuron tracts and in the circumventricular organs (water networks in the ventricular system of the brain) by means of corticotropin-releasing hormone (CRH), the pituitary gland by ACTH, and the adrenal cortex by cortisol (Koch, 2004).

The mammalian cell responds to all stress, including light stress, by increasing cholesterol production.

Cholesterol is the MAIN non-visual photoreceptor of the brain.  If you go into an ICU with a patient with an acute infection and draw their lipids (not often done except by a tool like me) you will find sky-high LDL cholesterol.

And that is both LDL and HDL, but the LDL fraction is much higher. Is that a problem? No. But Big Pharma has trained centralized MDs to reflexively reach for the Rx pad to write for a statin. This is why so many people with Bipolar disorder also have metabolic syndrome as a comorbidity as well.  Their LDL is high because they are all solar deficient.  Remember LDL cholesterol lacks electrons relative to HDL cholesterol.

The other non-visual photoreceptor in the brain that is common is melanopsin and it is found in the blood vessels.  Blue light at night, increases cerebral blood flow and increases blood pressure excessively.  High blood pressure is part of metabolic syndrome.

Few MDs & psychiatrists today are trained to even know full spectrum sunlight lowers cholesterol naturally.  Even fewer realize sunlight is the best treatment option for Bipolar disorder.  Most of them have no clue that the light where most humans have bipolar disorder is not strong enough to get rid of deuterium.  Blue light at night is an additive effect that makes this disease deadly.

This is why there are several formats of this disease as you saw in the video above. That mimics heteroplasmy in the system.

In fact, in metabolic syndrome, higher LDL cholesterol stabilizes the inner mitochondrial membrane function during heavy oxidative phosphorylation (cellular energy production). So a raised LDL actually helps mitochondria retain its electric charge to condense H+ inside the mitochondrial matrix to make energy using the light hydrogen isotope.

This is how the cell controls space time and magnetic fields inside of their tissues to ACCURATELY SIMULATE THE PHYSICS OF YOUR ENVIRONMENT.

^^^^That idea was in the recent Time Crystal blog.  Did you read it?  

In bipolar disorder, this is a broken mechanism at the level of the SCN because there are atoms in it with higher masses than there should be.  (D > H+)

Do you know what sits really close to the outer mitochondrial membrane in most mammalian cells?

POMC waiting to create melanin from the biophotons released from the mitochondria right next to it. Making CO2 and DDW is the reason our cells stole bacteria 600 million years ago. And since the cell is trying to recover from a light stressor, it needs a good inner mitochondrial membrane in which to transfer its electrons to oxygen and use the H+ liberated by melanin buried in water to make ATP by the spinning ATPase Fo head.

When the deuterium isotopic variation mechanism is broken in the SCN, lithium can be used to help offset that loss in the CSF networks in the ventricular system of the brain.  Effectively, lithium is adding mass to the water of CSF to offset the deuterium in the SCN to allow it to act as a better FM radio antenna to tell the season for the brain.

That is why lithium can help some of these people.

Lithium creates huge electric currents in cells.  This is why cells do not use it under our solar spectrum.  The problem with lithium is that it can never reverse the disease and you'll get that when you understand the physics of this disease.  

Only strict sun tropical exposure during the day and EXTREME darkness at night can repair the broken mechanism at the SCN level to help eradicate this disease in humans.  When the SCN is loaded with too much deuterium, as such, it cannot accurately tell time at all.  It will do best on June 21st.  In people with BD on lithium this is when the strong sun can set them off because that light can overpower their system because lithium creates massive uncontrolled electric surges in tissues because of its atomic size and spin.  

The isotopic variation of hydrogen changes in their tissues as their choices in light vary leading to mania and depression cycles in things the ipRGCs link directly to.  Note the positioning of the habenular nucleus in the next two pictures and you'll see the circuit manifest before your eyes.

What controls the autonomic nervous system in the gut of mammals that get metabolic syndrome?

NEUROANATOMY LESSON TIME:  POMC does because it is found in high concentration normally in the outflow tracts of the neurons from the hypothalamus that connect the hypothalamus to the gut.  This connection is made via the dorsal longitudinal fasciculus.  That is a tract I have not taught you too much about.  

That tract targets the thoracic nerves that connect to somites where other melanin stores are located from the neural crest. (key point) 

Remember before when I told you bipolar people tend to have pale trunks and abdominal skin?  Where do humans have the most POMC in their skin?  Thoracic and abdominal skin.  Now you know why this link is important.  These dermatomal layers need melanin renovation CONSTANTLY in BD to get rid of deuterium.  Where is the deuterium below?  It is in the enlarged ventricles and in the white matter tracts that have all these white spots in them below.  

When I see a patient with BD I always examine their skin in these areas before I order an MRI (above).  Why?  

Pale skin in these areas always correlates to white matter lesions in the brain (shown above).  Centralized science is still clueless why this is the case.  You no longer will be.  This is decentralized medicine 101.  

White matter hyperintensities (WMH) are much more common in subjects with bipolar disorder (BP) than in healthy subjects.  The more prominent that lesion or the larger their ventricles tell me how severe their disease is.  LINK   I have also observed that the paleness of the skin in these areas also correlates with the thickening of the choroid on OCT images of the retina and with changes in the inferior nasal retina on my eye exams.  today I saw three patients with altered ventricular anatomy in the ER.  I expected it.  The ED doctors did not.  

The hypothalamus is the key brain site for central control of the autonomic nervous system, and the paraventricular nucleus is the key hypothalamic site for this control. 

Much of the medial surface of the thalamus and hypothalamus form the wall of the third ventricle pictured above. Part of the hypothalamus forms its floor. 

Its thin, membranous roof contains the choroid plexus that makes cerebrospinal fluid which is 99.8% water. The third ventricle narrows quickly at the posterior end of the mammillary bodies.  These mammillary bodies are the key to memory formation and are important in dreaming during sleep.  When you do not dream and cannot remember it I know exactly where your POMC defect is. I know what to look for on MRI. 

Anatomically, the PVN is adjacent to the third ventricle, and many of its neurons project to the posterior pituitary. These projecting neurons secrete oxytocin and a smaller amount of vasopressin, otherwise, the nucleus also secretes corticotropin-releasing hormone (CRH) and thyrotropin-releasing hormone (TRH).

Recall my Brain-Gut #16 blog told you that the PVN is where adrenal fatigue began.  It is a light disease that turns off POMC in the hypothalamus and is not a real adrenal disease.

The PVM neurons massively express POMC but without UV light this switch never gets turned on. Bipolar patients are all lacking that critical UV light switch.  That means this pathway is turned off or is suffering a brownout.  You do not have a vagal problem, you have an autonomic nervous system slow down due to a lack of charge density there.

The major pathway from the hypothalamus for autonomic control is the dorsal longitudinal fasciculus in the human brain.  Below is another picture of the third ventricle (red box) that is adjacent to the hypothalamus and thalamus in humans.

The dorsal longitudinal fasciculus (fasciculus of Schutz) is a periaqueductal (area around ventricular system Aq above) ascending and descending fiber system arising from the hypothalamus and terminating to the autonomic nuclei of the pons and the medulla, conveying autonomic fibers from the brain to the gut in humans.  It also conveys pain messages and is important in the sleep pathways of humans.  These are usually altered in bipolar patients as well because of a lack of melanin in these areas.

The dorsal longitudinal fasciculus is found within the dorsal brainstem tegmentum. It passes through the periaqueductal gray matter and contains both ascending and descending fibers. The ascending fibers pass from the reticular formation (sleep region/insomnia) passing to the hypothalamus thus transmitting information related to the viscera in the thorax and abdomen.

People who travel a lot across time zones or people who use a lot of blue light or nnEMF at night or day in their cities are going to have massive sleep disturbances because they lack charge density in this spot.  They mimic people with mental disorders like bipolar patients because they have broken the same rules of Nature.  I view insomnia as a mental disorder in my decentralized medicine framework.

This topologic neuronal surface is a critical barrier to the brain health of humans.  This is the pathway where metabolic syndrome, poor sleep, and fatty liver all come from fundamentally.  This pathway could be in many blogs but I left it out this detail.  Why?  You already thought this stuff was too hard.  Why add another level of complexity with neuroanatomy?    

Many of these same findings are found in diabetics, bipolar disorder, and those with sleep disorders like insomnia.  Patients with bipolar disorder tend to have all these symptoms at times that vary based on how defective their FM antennae are in their eyes & brains.  

This explains how a lack of sunlight leads to most gut and sleep issues modern humans face. Without proper DLF input to the gut via the brainstem, ferroelectric currents are lost and circadian control of the gut lumen is awry. None of their molecular clocks work there as a result.  This opens the gut barrier to many potential problems.  Every patient I have seen with a gut issue has this common mechanism.

Pro-opiomelanocortin co-localizes with corticotropin-releasing factor in axon terminals of the noradrenergic nucleus locus ceruleus.  It is not just a PVN story folks. Where the problems lie will determine aspects of the disease you get.
This nucleus is filled with neuromelanin. 

Why do bipolar patients struggle with drugs and pain meds 7 the placebo effect? 

The locus ceruleus (LC), a small brainstem nucleus, is the primary source of the neuromodulator norepinephrine (NE) in the brain. The LC receives input from widespread brain regions, especially the hypothalamus, and projects throughout the forebrain, brainstem, cerebellum, and spinal cord.

What is the main function of locus ceruleus?

It is the brain's main source of the neurotransmitter noradrenaline (norepinephrine). This chemical is excitatory and is released in response to pain or stress, stimulating what is referred to as the 'fight-or-flight' mechanism. This means that it activates the sympathetic nervous system via those thoracic nerves I mentioned above.  

Those are the same nerves that innervate your brown fat and also give input to the superior cervical ganglia that I mentioned in Time 12 blog long ago.  Without UV light exposure in the eye and skin in these dermatomes melanin is degraded and noradrenaline is diminished.  You remember that noradrenalin can be made from melanin right?  You need highly oxygenated environments to keep noradrenalin stored and when the flight or fight response comes the hypoxic effect changes how the system operates.  NA can be degraded to L-DOPA to make other chemicals needed in many places of the brain. See the slide below the far right top line.

Neuropsin is a 380 nm light sensor that the locus ceruleus needs to function well.

Without this non-visual photoreceptor system operational, this opens the BBB and the gut barriers. Now you see why Nature put neuropsin in your eye and skin.  We see this in most psychiatric cases and in TBI cases due to the light stress response.  Now you can see why really the brain-gut barrier is linked. Usually, there is a lack of melanin in the DLF and/or the locus ceruleus to create the aura of brain-gut barrier when in reality what links the two is a lack of UV light to stimulate POMC in both hypothalamic pathways and melanin is degraded leading to many disease phenotypes.  

Each somite in the spinal cord also has POMC genes in them ready to be activated.  They are derived from the neural crest in this part of the body.  For the gut, this is linked to the celiac ganglion which comes from T5 -T11 thoracic nerves.  So thoracic level solar exposure is key to renovating gut-level melanin.  It is counterintuitive until you see it all laid out in front of you.  A lot of this deep science would have been in the Vermont 2019 video I was going to give 4 years ago.  I think I still might do it for the Kruse for Dummies folks as their next lesson.

SUMMARY

Neil Cherry Ph.D. from New Zealand showed in 2002 that there is strong and robust scientific evidence of the human brain detects and responds to the Schumann Resonance signal based on the work of many researchers Robert O. Becker worked with in the 1970s.  People with bipolar disorder cannot connect well with the Schumann resonance because of excess mass contained within the receivers of the signal which comes from the sun and Earth.  As a result, this leads to behavioral and neurologic dysfunction.  Since the increased mass of isotopes used in this system affects coherence times that are possible in cells, they lose their ability to maintain quantum coherence and the system becomes dysfunctional.  How long a system can maintain coherence is a function of the atomic mass in that system.  You can see now why any additional masses in the SCN or habenular nucleus destroy this relationship.  The pictures below show the specific details of the pathology laid out for you.

The brain uses a range of frequency patterns monitored by the EEG system in our neurosurgical clinics. The frequency range of the EEG rhythms coincides with the frequency range of the Schumann Resonance signal (0–45Hz). The alpha wave is identical to the frequency most commonly linked with Schumann's resonance on Earth.  The normal brain has developed an ELF oscillating ion system, primarily using calcium ions (above), to control neurotransmitter release.  The release is awry in BD.  Dr. Russ Adey at UCLA established this in the 1970s.  Adey's work is cited below. The human brain and its optical clock lattice in the SCN are now well-established in the literature.  

Blackman's work on calcium ion resonance frequencies was cited multiple times in Becker's books and my early blogs on the non-ionizing effects of nnEMF and neurological compromise. Blackman's research also cited below, has taught decentralized MDs that external electromagnetic ELF signals induce altered neuron calcium ion effluxes in mitochondria of brain tissue.

These ELF signals between the sun and Earth are weak, yet they match the ultraweak UV biophotons that cells create in response to the Schumann extraterrestrial signal.  This allows the brain to know the season.  The stable synchronization of the brain's electromagnetic systems using a system that mimics an FM radio has actually led to humans becoming thinking, emotional, and memory machines of biology that are capable of quite a bit of intelligence in the human central nervous system. In order to carry out these functions the brain has developed electromagnetic transmitters and receivers in the neurons to accomplish this task in the SCN, leptin melanocortin pathway that extends into the thalamus of man and into his spinal cord.  The thalamus is where the alpha wave finds its genesis in humans. This connection is pictured below.

The receivers used by Mother Nature mimic an FM radio in your car.  Yes, the human brain has a built-in FM radio system.  I was not joking above.  In the human brain, there is included a phase-locked loop system, described by Ahissar et al.  This paper is cited below. 

A phase-locked loop system = modern FM radio receivers in your car.  

In the human brain, the FM radio receiver interacts with the Schumann Resonance signal.  The phase-locked loop is a very useful circuit block that is widely used in radio frequency or wireless applications in tech gear.  Given its usefulness, the phase-locked loop or PLL is found in many wireless, radio, and general electronic items from mobile phones to broadcast radios, televisions to Wi-Fi routers, walkie-talkie radios to professional communications systems, and much more.

Mother Nature built this system over 3 billion years ago in the brains of living systems to inform cells of the seasonal connection between the sun and Earth so this data could be useful for seasonal biological changes in living things.  In bipolar disorder, this system is awry when it is encumbered by too much mass in the receivers of the FM radio.

The circadian activity generated in the SCN needs to be transmitted to the rest of the brain and henceforth to the rest of the body via non-optical signaling to stay well. In Bipolar Disorder this is impossible because the SCN is where the main deuterium defect lies.  

That EMF receiver is not receptive to Schumann's information.  Coherent connection ruins the fidelity of the system.  Most of the centralized science right now believes it is through direct wiring tracts. I do not. I think it happens via the hydrogen bonding network in the circumventricular organs filled with CSF water.  These areas in your brain have no blood-brain barrier by design.  

This provides the fidelity of the phased locked loop design. This allows electron and proton tunneling and quantum coherence to allow for rapid communication in the system. I believe all biological processes in any living organism are due to the creation of biological biophotons in the ultraweak VUV-IR-A range. Light can dictate highly selective and specific electromagnetic interactions between particular biomolecules because of changes in mass or the magnetic moments of the component boxcars of biochemistry. In most cases, these interactions involve and are driven by semiconductive proteins surrounded by water, which act as logic gates do in the system of organization seen in solid-state physics.

The human brain SCN contains the key mechanism to having a strong diurnal pattern that assists the sun to maintain the circadian rhythm.   The Schumann Resonance signal continuously synchronizes the brain wave ELF patterns in a set range of grouped frequencies that begin in the thalamus that surrounds the 3rd ventricle of the brain.  The ventricular system also acts as a resonant cavity on Earth to receive these signals.  

The hydrogen bonding network in CSF is another FM-like receiver in the phased locked loop communication system mentioned above.  This stabilizes the brain's electromagnetic system of communication and its fidelity has enabled the evolution of intelligence and consciousness with an ability to provide stable thinking to make predictions.  This system has evolved to the point in humans where this complex understanding of the biophysical environment interacting with the human brain can be reasoned, understood, and appreciated.

DNA only codes for the key backbone proteins that will become the main conductors of any life process within the organism. The mitochondrial matrix created the other part (water hydrogen bonding network) of this semiconductive backbone in cells to surround the protein.  Both parts of the semiconductor have to be operational to simulate time from your environment at the level of the SCN.  Everyone focuses on refraction errors in the eyes.  Few spend time understanding how the eye clock really operates at a quantum mechanical level with the Schumann frequency.  This is why psychiatry remains impotent to help reverse this disease.

Let's review the lessons from 100's my blogs now in relation to this disease.

A. Hydrogen bonds form between water molecules, giving rise to supramolecular aggregates/clusters/coherent domains. Some call this EZ water.  The clustering of water is a cooperative phenomenon, which means that forming one hydrogen immediately favors the formation of several other hydrogen bonds, and vice versa, breaking one bond leads to breaking up a whole cluster. Thus clusters are dynamic flickering networks with lifetimes of 10^- 11 to 10^-10 seconds. Light changes those hydrogen bonding networks by moving charges around.
https://phys.org/news/2022-10-revolutionary-technique-hydrogen-efficiently.html

B. Hydrogen bonds are the key to coherence in cells. Hydrogen bonds act like a spec of dust in the formation of snow, ice, or crystals.

How do coherent excitations make the system sensitive to specific, weak signals? Such a weak signal will be received by the system only when the system is ‘in tune’ — rather like a very sensitive FM radio receiver, which can resonate to the signal. Furthermore, a small signal will be greatly amplified for it will not only affect one molecule, but because many other molecules are in the same state of readiness, they too, will be affected in the same way, and the signal is correspondingly multiplied as many times as there are molecules responding to it.

The shape of your ventricular system which is filled with H+/D is another clue for me that the receiver system is broken.

The hydrogen bonds in water have a critical point at which they change and act like dust. When enough energy is pumped in bond angles change and this makes water liquid crystalline and a better antenna to receive signals of what season it really is.  People with bipolar disorder have bad FM antennas.

More lessons from old blogs you need to recall now to understand Bipolar:

C. Sunlight creates electric fields in our atmosphere every day and that sunlight creates a Coulomb force in our body. Coulomb force is an electrostatic force. Electrostatic phenomena arise from the forces that electric charges exert on each other. Coulomb's law describes such forces. Even though electrostatically induced forces seem to be rather weak because of how we experience them in life, when the scale shrinks, as it does in a cell, the electrostatic force increases tremendously in strength as the scale drops. Scale drops = less mass present

D. For example, some electrostatic forces such as the one between an electron and a proton, that together make up a hydrogen atom, are about 36 orders of magnitude stronger than the gravitational force acting between them. The electrostatic force generated in your skin is another example of a strong electrostatic force because the skin, as an insulator can hold large amounts of charge from the sun if it is normal.  It is not in bipolar disorder.

E. Modern physics now has proven that energy and information are equivalent in physics. Landauer's Principle of 1961 & Shannon's 1948 work was critical in making this linkage. Modern quantum biology has experimentally proven that energy is trapped directly at the electronic level in cells. Energy is stored not only as vibrational and electronic bond energies in biochemicals, but also in the structure of the system: its membranes, and in gradients, fields and flow patterns, compartments, organelles, cell water, and tissues. All this in turn enables organisms to mobilize their energies coherently at any time it is needed and hence make available the entire spectrum of stored energies for physiological work. It is energy on demand by atomic design.

F. What is the bandwidth of the entire electromagnetic spectrum of light? The electromagnetic spectrum starts from wavelengths of 10^-14 m at one extreme to 10^8 m at the other, spanning a range of 10^22. In terms of doublings, 10^22 ≈ 273, or 73 octaves. Visible light is a small fraction of this bandwidth but that bandwidth does very specific things that cells take full advantage of.


Light is an EMF. Sunlight (visible light) is a very specific EMF that interacts with specificity for atoms in cells. That specificity is created because the EMF selects the type of water created by the dissipative system. This DDW water surrounds the atomic lattice inside cells whose integrity is maintained by the nuclear genome blueprint. The atomic arrangement in cells also allows for light absorption and light emission. The light that cells emit is also quite specific. It is an ultraweak extreme low-frequency biophoton that spans the visible spectrum frequencies. This is the light that is used for optical signaling and it drives the molecular resonances that drive the internal motions of biochemicals in cells. Light drives biochemistry. Biochemistry does not drive light.  

Conventional centralized biochemists do not understand these nuances of what biophotons are and how they are created by EMFs, water, and oxygen in cells. So You should not expect centralized physicians (psychiatrists) to get this nuance either.

G. Claude Shannon taught the world that information flows via entropy. All clocks should be thought of as flowmeters for entry. This includes the biological circadian clocks in cells. Wheeler taught physics that information and energy are one and the same thing. Shannon’s mathematics from his 1948 paper advanced the linkage of entropy and information. Shannon's paper also told us anything can be a message.  (Kruse for Dummies lecture)  H+ and electrons are fermions.  Deuterium is a boson and this small difference can ruin how an FM antenna works.

I believe sunlight messages for mitochondrial DNA and nuclear are controlled by "fermion messaging" (pic above from old blogs). DNA is informed about what to do with optical information from the sun via mtDNA signaling (optical and free radical) and this message is transmitted over water's hydrogen bonds adjacent to proteins in a cell. DNA is a very complex topologic insulator that is an antenna for our star's information.

H. Water makes up 99% of molecules in every cell and it fills the ventricles of our brain. Water is a very small molecule that has more hydrogen bonds in it than any other compound. Liquid water contains the densest hydrogen bonding of any solvent, with almost as many hydrogen bonds as there are covalent bonds and hydrogen bonds in its structure found anywhere on Earth. These two bonding networks are the binary code in water. Just as a computer can use a 1 and 0 to create digital information on the internet, hydrogen bonds create the internet in your cells. Shannon taught us the information content of any kind of message could be measured in binary digits or just bits. This was the basis of the Kruse for Dummies talk.

I. Water's hydrogen bond network changes at a pico and femtosecond level in any environment. Inside a cell, its atomic arrangement is controlled by electrostatic forces in a cell created by the redox power of the mitochondria in that cell. These hydrogen bonds can rapidly rearrange in response to, light frequencies, charge density, and changing conditions and environments (for example, solutes like K+ in a cell).  This is how our ventricles tell seasons in us.  

It is also how neurosurgeons should use MRIs differently to diagnose clock disorders in their patients.  I know I do it every day.  Normal pressure hydrocephalus for me is diagnostic of a brain filled with deuterium and a completely disordered clock system.  These people are walking time bombs for intracranial clots and neurodegeneration.  POMC is degraded massively in these patients.  

When the FM system is bad in the neocortex, brainstem, and  thoracic spinal thalamic tract you cannot tell seasons and bipolar disorder is the result. 

J. Shannon demonstrated, contrary to what was commonly believed in the 1940s, that engineers could beat their worst enemy ever: transmission errors-or in their technical jargon, "noise." Noise is anything that disturbs communication. Your FM radio antenna does not work when there is noise in the system.  It can be an electric signal in a telephone wire that causes crosstalk in an adjacent wire, a thunderstorm static that perturbs TV signals distorting the image on the screen, or a failure in network noise to increase the energy of the transmission signals or send the same message repeatedly-much as when, in a crowded pub, you have to shout for a beer several times. Shannon showed a better way to avoid errors without wasting so much energy and time: coding. 

Nature does the same thing.

She takes the message in the hydrogen bonding network of water that surrounds every protein and encodes that information in fermionic code in mRNA, mtDNA, RNA, tRNA, and DNA. Deuterium is a BOSON.  It ruins the fermionic signal and that CAUSES bipolar disorder.

DO YOU GET IT YET?  

K. Coding is at the heart of information theory. All communication processes need some sort of coding to limit the noise and create a high-fidelity signal that doesn't degrade. Bipolar disorder is due to tissues in our FM radio station in our heads having too much mass in them.  Water preserves the information and transfers it to nucleic acids via hydrogen bonds. Just as the telephone system transforms the spoken voice into electrical signals. In Morse code, letters are transmitted with combinations of dots and dashes. The DNA molecule specifies a protein's structure with four types of genetic bases. Digital communication systems use bits to represent or encoded information. Each letter of the alphabet, for example, can be represented with a group of bits, a sequence of zeroes, and ones. You can assign any number of bits to each letter and arrange the bits in any way you want. In other words, you can create as many codes as desired. Cells have done this to run life's program.  

The more mass a tissue has the less time it can remain quantum coherent to transfer information in any system.

All of these lettered lessons above ^^^^^ have been published in my blogs or forum for years.  Please ASSIMILATE THEM NOW.

If you do not believe me review this thread:  https://forum.jackkruse.com/threads/mitochondrial-thermodynamics-diy-lesson-thread.27408/

This blog was easy to write because pieces and parts of it are in hundreds of other blogs.

The emission and absorption spectra of proteins can be used to make predictions of what light frequencies will couple with proteins and the matrix to create DDW water. The logic in the system of operation can only be comprehended when you understand how the subatomic parts of nature are able to be used and manipulated by quantum mechanical abilities. I told you a long time ago, in the Cold Thermogenesis series, that the default state of life was sleep.  Then as evolution progressed with evolved wakefulness.  This idea was counterintuitive to many at the time.  The reason for my prediction was simple.  I read Feynman's 1982 paper on a computer simulating the physics of the environment and thought to myself what organ in humans fit his description of an ability to simulate the physics of Nature?  The SCN fit perfectly.

The SCN filled with deuterium and your CSF overwhelmed by deuterium is where bipolar disease comes from.  Patients with Bipolar Disorder also have a higher risk associated with retinal detachment, primary retinopathy, diabetes retinopathy, big ugly ventricles, hypertensive retinopathy, and retinal vascular complications than the controls.  Now you all know why this blog came after the last one.  The symptoms begin in the eye and retina.  

Please re-read QE # 44-47 again.  The concepts are there to explain this disease and all sleep disorders.  The last blog was on diabetic retinopathy.  Those patients also always have features of metabolic syndrome.  So do most mental disorders and sleep disorders.  Now you can see why they are all linked.  You have effectively broken the FM antenna station nature put inside your skull.  If you have insomnia, (yes, Sam this was for you before I banned you)  part of your system in the periaqueductal grey area is broken in your brain because you loaded this area up with deuterium by using Netflix too often while traveling outside your time zone too much for your brain, and you decided to live in Chicago with all its associated nnEMF and population density.  It should be obvious why you cannot sleep under these circumstances, no?

What I am explaining to you now is where in the topological map of the human brain the POMC deficit is located leads to the phenotype of the disease we see in our clinics.  Patients with this disorder intuitively know they need more sun.  How they go about it is often incorrect as you see in cite 4 below.

Understanding the human eye and retina and linking it to entropy in a cell was the only quantum leap I made to understand this concept.  The flow of entropy is why I made this prediction back in 2010.  All molecular clocks are flow meters for entropy.  I knew the SCN had to be doing something unusual with the retina and the brain during sleep.  The SCN appears to be a perpetual motion machine built into the brain.  Feynman wrote a paper in 1982 stating he believed a quantum computer could simulate physics if it used a time crystal.

The SCN is a small computer in your eye that is simulating the physics of the environment between the sun and Earth to make the best predictions for cells in tissues.  In bipolar disease that time crystal is not working well because the mass inside of it put there by the light you allow ruins it.  Adding mass back to the water networks, using lithium is how lithium operates.

The problem is the system fidelity operates at quantum mechanical precision with respect to mass and this is why results are so uneven in patients with this disease.

GAME, SET, MATCH

CITES

https://www.psychiatryadvisor.com/home/topics/mood-disorders/bipolar-disorder/increased-metabolic-syndrome-prevalence-rates-linked-to-newly-diagnosed-bipolar-disorder/

https://www.patreon.com/posts/quantum-44-your-83629619

https://pubmed.ncbi.nlm.nih.gov/34994991/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860187/

Adey W. R. Electromagnetic fields and the essence of living systems. In: J. Bach Anderson (ed). Modern Radio Science. Oxford University Press; 1990. p. 1–37.

Ahissar, E., Haidarliu, S., Zacksenhouse, M., 1997. Decoding temporally encoded sensory input by cortical oscillations and thalamic phase comparators. Proc. Nat. Acad. Sci. USA 94, 11633–11638.

Blackman C. F. ELF effects on calcium homeostasis. In: B. W. Wilson, R. G. Stevens, L. E. Anderson (eds). Extremely low-frequency electromagnetic fields: The question of cancer. Columbus: Publ. Battelle Press, 1990: 187–208.

Cherry N. J. Schumann Resonances, a plausible biophysical mechanism for the human health effects of Solar/ Geomagnetic Activity. Nat Hazards 2002; 26: 279–331.

"We live by a small trickle of electricity from the sun.” The green of our garden, the algae in our water, the trees, grasses and herbs on our lands are the transforming agents that harvest the sun’s light via the process of photosynthesis. When we consume these foods, this stored sun energy is released into our bodies as electrons; it is then transformed into ATP, adenosine triphosphate, the biological energy necessary for all cellular function.”

- Albert Szent Gyorgyi

Why would a lighter version of hydrogen affect survival?  What is is about the relation of mass to bond energy or charge that affects longevity?

Mitochondriacs should remember that the mitochondrial matrix concentrates hydrogen protons as part of its physiologic capabilities.  They should also remember that when sunlight hits water in a cell, coherent domains are made in water (coherent domains in water) that liberate protons and exclude anything the size of proton or larger.  Deuterium has a higher mass (double) and is atomically larger. It also has a different nuclear spin and this means it has a different magnetic moment.  Dueterium has a proton and a neutron and one electron.   Anything that is larger is harder to quantum tunnel because the inherent energy barrier is higher to overcome.  So it appears life has several reasons to favor "light hydrogen" that has very little deuterium.

SIDEBAR FOR THE CURIOUS:  The mass of the deuterium nucleus (2.01355 u) is less than the sum of the masses of the proton (1.00728 u) and the neutron (1.00866 u), which is 2.01594 u. Where has the missing mass (0.00239 u) gone you ask? The answer is that the attractive nuclear force between the nucleons has created a negative nuclear potential energy–the binding energy – that is related to the missing mass, (the difference between the two masses). The light photon released in forming deuterium in stars has an energy of 2.225 MeV, equivalent to the 0.00239 u required to separate the proton and neutron back into unbound particles. The nuclear decay photons are, in general, higher in energy than photons created in atomic processes.  This makes sense in the light of E=mc^2.

What type of water does Earth have?

The origin of Earth’s water has puzzled scientists for decades. Icy comets smashing into the planet seemed like natural donors, but many comets have water chemistry that is isotopically different from that of Earth’s oceans. The current paradigm believes that rocky asteroids that contain water might have soaked our young planet.  I don't buy this at all.  Recent analysis of meteorites—the asteroids’ remnants on Earth—show that our planet today is missing the material that those impacts should have left behind in hydrogen isotopes.  So this raises the question where did the water that is on Earth today come from?

Cosmology's opinion today is thus:

Research recently published in the Journal of Science provided evidence for a different theory: it says that water has been around since the Earth formed.   They believe it was trapped in the mantle of the planet much like an avacado protects its water in its flesh.  They proposed that the water was bonded to grains of dust that aggregated to make our planet and locked the water within the core.  This sounds a bit like how clouds form in the sky.  Does this "theory" account for all the water we have today on Earth?  No it does not.  Does it account for the isotopes in bulk water?  No it does not.  The data is quite interesting for the mitochondriac.  So what gives here?  Measurements of ancient volcanic rock suggest that only 20% of Earth's water might have such primordial origins.  So where did the remainder of the 80% come from?  They say don't know where it came from but they know it was here a lot earlier than the theories in their textbooks.  So where might it come from?   I have an idea.

Recall that life on Earth has been around for 3.8 billion years.  The earth is around 4.4 billion years old.  Two kingdom's of life existed from 3.8 billion years ago to about 650 million years ago.  Those two kingdoms where Archea and Bacteria.  650 million years ago chloroplasts shows up in the seas.  They came from bacterial origins.  50 million years later mitochondria showed up at the Cambrian explosion.  They also came from bacteria and the current anatomy of mammalian innermitochondrial membranes contain that truth.  It has no DHA in it.  The formation of a mitochondria from bacteria allowed for the third kingdom of life to explode.  This was the kingdom of eukaryotes from which all complex life comes.

Why am I giving you this history lesson again?

What are the byproducts of mitochondrial respiration?

Water, carbon dioxide, and melatonin.

Over 3.8 billion years could ancient bacteria and eventual successors, mitochondria, have accounted for the remainder 80% of water on the surface of Earth?

I think so.

Take a look at the picture below.  Bacteria were on Earth far before photosynthetic reaction was innovated by evolution on Earth. Since bacteria are capable of making water it stands to reason that a bacteria would have been stolen first to make a chloroplast that consumes water with CO2 and sunlight to make sugar.   Hydratase enzymes are present inside of mitochondria where the tricarboxylic acid (TCA) cycle helps control cell growth and depletes deuterium from redox cofactors, fatty acids and DNA, which undergo hydride ion and hydrogen atom transfer reactions.

In eukaryotic cells, the citric acid cycle occurs in the matrix of the mitochondrion. In prokaryotic cells, like bacteria who lack mitochondria, the citric acid cycle reaction sequence is performed in the cytosol.  This is also lost on most centralized scientific bystanders.

(The nitrogen cages (nitride) that makes electricity from sunlight)

The citric acid cycle = the tricarboxylic acid (TCA) cycle =  the Krebs cycle.

It is a series of chemical reactions used by all aerobic organisms to release stored energy through the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins into carbon dioxide and chemical energy in the form of adenosine triphosphate (ATP). In addition, the cycle provides precursors of certain amino acids, as well as the reducing agent NADH, that are used in numerous other biochemical reactions. Its central importance to many biochemical pathways suggests that it was one of the earliest established components of cellular metabolism and may have originated abiogenically.  This fits with the story of water being built in this  blog entry.

So why would deuterium depleted water improve survival in a disease?  Could this idea be used to prove that cancer really is a mitochondrial disease and not  nuclear genomic cause?  I think so.

WATER HIT BY SUNLIGHT VISCOSITY CHANGES

Sunlight affects the spinning head of the ATPase.  If the size of the protons that runs the spinning head is substantiall larger because of a change in mass or viscosity it will effect the spin rate of the ATPase and the amount of ATP made.  Previous work assumed that ATP synthase, the smallest known rotary motor in nature, operates at 100% efficiency. Calculations which arrive to this result assume that the water viscosity inside mitochondria is constant and corresponds to that of bulk water.   Bulk water is more like deuterium depleted water because it does not have a lot of deuterium in it.  When deuterium makes up a large portion of water not enought ATP can be made because of the viscosity change due to the isotopes of hydrogen. Mass affects bond lengths in chemistry so the charge separation of water in a cell with deuterium is much higher.  This would massively effect hydrogen bonding in bio-chemical reactions.   Hydrogen without any neutron is protium and life likes this isotope. Hydrogen with one neutron is deuterium.  Since a neutron weighs just a bit more than a proton, deuterium is slightly more than twice as heavy as protium. Protium is a hydrogen proton with its electron.

In the first three resiratory complexes there is 3 de-hydrogenases that strip hydrogens from foods.  These hydrogen atoms then have their electrons stripped from them in the mitochondrial matrix.  The matrix collects H+ in massive quantities.  There is another system adjacent to mitochondria that also charge separates water into H+, oxygen, and electrons.  That is endogenous melanin.  (pic above)

The ATP motor runs on protons without their electron going from the matrix into the outer mitochondrial membrane space to make ATP.  This quantum red light motor spins at 9000 times per minute. It is designed to accept a proton stripped of its sole electron and not deuterium.  There is no way a proton and neutron are going to fit in this nano-motor channel.  (picture below)  If the hydrogen proton that runs this motor has a larger mass (deuterium), it will not work anywhere near 100% efficiency in the ATPase.  This slows the amount of energy made and transferred in cells.  This is why the video above shows the effect it does.  Deuterium depleted water improve mitochondrial function because it increases energy flow by allowing protons to move through the motor at 100% efficiency. This strongly suggests we have more proof that cancer is a mitochondrial disease at is core.  

I want you to remember that water and cytochrome C oxidase are red light chromophores.  I also want to remind you that 42% of sunlight is IR-A light.

There are 4 key spectral frequencies between 650–980 nm are absorbed by components of cytochrome c oxidase in mitochondria. The stoichiometry and absorption spectra of cytochrome c oxidase components a and a3 has broadened based upon new recent data. The older footprint spectra that showed peak activity was visible light at 550, 605 and 655nm and near-IR light at 830 nm.

Water that is depleted of deuterium and irradiated by red light is more energenic than than water loaded with deuterium because of the relationship of charge to mass in physics.  Heavy water does not work as well inside the ATPase of the mitochondria. The presence of deuterium in water gives the chemical different nuclear properties and effects how the ATPase can spin. Moreover, the increase of mass gives it different bio-physical properties compared to normal "light water" irradiated by light.

How does light effect charge in plants and animals?   The effect of porphyrins answers this question.   Plants (Mg porphyrins) and animals (Fe porphyrins) use nitrogen based cages in chloroplasts and hemoglobin in different cells to make electric charge from sunlight.

What does this mean to a mitochondriac?  Where there is matter (deuterium), there is a specific geometry.  This geometry ties to the size and shape of things and size and shape correlate to the thermodynamics possible in a cell.  Where geometry ceases to exists, gravity vanishes and we find an abundance of light.  This is why at small scales gravity has a neglibile effect in physics.   Where there is light and matter we see time manifest in cells.

The universe is governed by four fundamental forces.  But when it comes to understanding nature at almost any level larger than an atomic nucleus and smaller than a planet, only one of them really matters: the Coulomb interaction.

COULOMB'S LAW: gravity and EMF forces in a cell:

There is a mathematical parallel between gravity and electrostatics.  The force equations for both forces are similar, so the behavior of interacting masses is similar to that of interacting charges, and similar analysis methods can be used to compare them. The main difference is that gravitational forces are always attractive, while electrostatic forces can be attractive or repulsive based upon charge.  Charge is a conserved quantum mechanical quality in particles like protons. 

The charge (q or Q) plays the same role in the electrostatic case that the mass (m or M) plays in the case of the gravity. The key for the 'mitochondriac' to realize is that size causes gravity to lose its attractive power in cells.  The smaller the scale the less powerful gravity become.  Conversely, as scale decreases electrostatic force become very strong.  This is why water is confined to small scales in cells in carbon nanotubes and around the cristae.  It is done to negate the effect of gravity and maximize the electrostatic charge that increases massively as scale is shrunk.  This is what happens in mitochondria which are organelles in your cell.  Some cells have 3-10,000 of them.  Electrostatics are capable of generating massive forces when this situation is allowed by nature.  It is one of the more novel and counterintuitive aspects life uses to dance on the ledge of the second law of thermodynamics.

This also explains why electric fields are prominent on sunny days and gravitational effects during the day are lowered than they are at night when sunlight is not present to charge things.  This is why circadian biology is fundamental to biology.  Sunlight can alter charges and night time balances the charge separation.  Charge is a quantized property in nature.  It is all related to the quantized effect of charge on things in nature.  The force exerted by one charge ‘q’,  on another charge Q is given by Coulomb's law.  This law clearly shows us that forces between two electrically-charged objects can be extremely large.

The structure of mass of deuterium determines the frequency of light it can resonate and this frequency dictates structure of plasmoid instabilities and the type of light that will work with it and what frequencies won’t.  It also determines how the ATPase will work when there is an isotopic variation.  Heavy water and the human ATPase are like oil and water.  They do not mix.

The electric charge developed by each protein then directly effects the charge to mass ratio in cells.  Charge affects thermodynamics of any system because of its relationship to size, shape and density in anything with mass.  Deuterium water is less capable of generating energy from the ATPase because of its higher mass.  So when heavy water replaces water in the extracellular and cytosolic space, light is less effective at making coherent domains (think EZ).  This means the capacitor function in the cell that coherent domains in water can form is limited with deuterium.  If this liquid crystalline battery cannot generate as much energy in animals and plants it will directly affect their longevity?  It seems obvious but no one in the video above seems to know why DDW extends longevity in all these cancers in mice and humans.  

This is why the video above shows the observations it does.  It is 100% bio-physical, and has nothing to do with the nuclear genome. It is 100% a story of how energy dictates what kind of anatomy is possible in a cell.  It is well known that an electric charge alters the space around it.  If a cell's capacitor is reduced for any reason, its charge or redox potential is also reduced.  The higher the charge present in a cell or anywhere in the cosmos,  the lower the mass we should expect to find.  We do not realize these relationships exist in biology at small scales in cells.

Deuterium has a higher mass than light water, and if it is found in our cells to any great degree replacing lighter hydrogen it means a cell cannot have a higher CHARGE.  This is why the relationship of charge and deterium fractions in our tissues is a LARGE one. In information theory Claude Shannon taught us that newswrothy messages have unusual characteristics.  This is what makes them notable.  Deuterium presence is a newsworthy signal that is sent directly to your telomere system in cells.  The altered Coulomb force shortens your telomeres and you get disease quicker and you will die sooner.  This is why sunlight shows a massive survival benefit in some many studies.   

Cells with a lot of deuterium cannot carry a higher charge when it is illuminated by sunlight no matter how much light one recieves.  This is why some patients Vitamin D levels won't budge.  It is a sign their tissues are filled with deuterium.  Now look at just how big a deal this is when you see the relative amounts of things in our plasma.

The effect is massive in cells because of the relative concentrations present.

There are two kinds of charge in the universe, positive and negative

Like charges repel, unlike charges attract

Positive charge comes from having more protons than electrons; negative charge comes from having more electrons than protons

Charge is also quantized in nature, meaning that charge comes in integer multiples of the elementary charge labeled as 'e' in most books.  Biologists forget charge is quantized.  Mitochondriac's better never forget this lesson.  When you consider all biochemical pathways operate via redox chemistry mechanisms,  this aspect alone, should carry a larger importance.  This is why I tell people just understanding biology from a bio-chemical level does not explain all the energy potential a cell can generate.  It also points out why mitochondriacs need to understand blood plasma well.  Blood is charged by light and discharges in darkness.

Charge is conserved in nature.  It is a universal law.  It is not an opinion.

What does it mean for charge to be quantized?

In other words, charge comes in multiples of the charge on the electron or the proton once they are separated by sunlight action on our bio-molecules. These things have the same size charge, but the sign is different.  A proton has a charge of '+e" , while an electron has a charge of "-e".  Both are used in mitochondria.  Protons are used in the matrix and electrons are used in electron chain transportation to reduce oxygen.

Putting "charge is quantized" in terms of an equation, we say:

q = n (e)

'q' is the symbol used to represent charge, while 'n' is a positive or negative integer, and 'e' is the electronic charge, 1.60 x 10^-19 Coulombs.

It has been proposed that deuterium depletion has a massive effect on  the terminal complex (cytochrome c oxidase) of mitochondrial electron transport chain in reducing molecular oxygen to deuterium depleted water (DDW).  This makes complete sense when you consider the bio-physics required in the ATPase and when you consider how electrostatic charging actually works in water networks.  When water has a lower atomic mass, this affects how the metabolic pathway of gluconeogenesis and fatty acid oxidation can procede in a cell.  It also effects the downstream metabolic pathways that use sugars in cells because of how light can or cannot move in a higher viscosity system.  This is key in DNA/RNA because both molecules are loaded with sugars.  Both metabolic pathways, (gluconeognesis and beta oxidation of fats)  in a mitochondria make water, C02, and melatonin.  All three link to longevity in mammals.  

Beta-oxidation make a larger volume of water on a relative basis.  Most people forget this relationship of water creation to metabolic flow in a cell.  It is critical to the redox potential in a cell.  The redox potential is how much work can or canno tbe done by a cell.  The water made by a mitochondria is always deuterium depleted because of the energenics in the ATPase mentioned in the November 2017 webinar and the last few blogs.

When water has a lowered atomic mass, it diminishes the deuteration of sugar-phosphates in the DNA backbone and places them in a specific location by design.  Photosynethesis carries this information to biochemical pathways.  Mitochondrial decode this quantum binary code in the isotopes of hydrogen.  When these chains of sugars have a lowered mass they have a significant bio-physical effect on the layers of water surrounding the DNA helix. This affects their topology. The 2016 Nobel Prize in physics was given for topology.

I believe that topologic insulators’s are buried inside of every base pair of DNA because of these changes in hydrogens of ribose sugars and they act like a superconducting magnetic films for life.  These changes occurs via light and temperature changes sensed by the mammals' exteriors.  The reason is that deuterium acts like an optical switch with light.  It is on this thin film of nucleic acids that life becomes of a perpetual motion machine (time crystal) of subatomic particles that allows life to continue unimpeded, as changes occur in energy in the environment.

This makes evolution rapid and complex and not gradual as biology has come to accept.  Topological insulators conduct electricity on their surfaces but do not conduct the current deep inside their cores.  This is why deuterium is found in high concentration in mammalian blood and not deep inside of our tissues.  This helps explain why DNA’s surface is highly coiled and coated with histones, chromatin, and methyl groups in its “quiet state” and how it can receive photo-electric instructions to run the epigenetic programming it contains deep within.  What happens on its surface can awaken the code of life buried deep below its double helix to change in its Dirac fermions contained in the ribose and bases.

Deuterium has a nother difference that illuminates this story.  Deuterium is a  boson not a fermion like H+.  This is why mammals are built as they are.  Few see what I see below the cell level.  

This is a scanning tunneling micro image of helical Dirac fermions on the surface of a topological insulator above.

The sugars effect the dynamic changes in the hydrogen bonding network and this effects epigenetic programing possible.  Many of these effects of epigentics are post translational changes made to proteins to change their topology that lead to altered physiologic function.  If the change i snot favorable it will lead to defected signals, and to ubiquitin marking which is commonly seen in most human cancers.   If the change is good evolution will advance.  These changes occur rapidly and not slowly and they cannot be seen well because of the scale they occur on.

When I gave a webinar 4 years ago on TI’s,  I said that soon science would prove what goes on the surfaces of things may turn out to be more important than what goes on beneath the surface.  I had a sense this deuterium issue in DNA and RNA are critical in changing the surface topology and the optical programs.  I made the comment because I felt photo-chemistry at surfaces was more important than solution bio-chemistry in cells below.   Topologic insulators in physics concern itself with the very bizarre properties of matter in extreme states, including superconductors, superfluids and thin magnetic films.  This is “what” the physics of organisms made from to create life.  Life is an exotic state of matter just like what we find on the surface of the sun.

These changes in the surfaces of DNA and RNA can affect how much energy transfer can occur in the water sheets, coherent domains, or exclusion zone.  All are critically connected to the electrostatic force (redox) possible in a cell.  The larger the EZ the higher the redox, the higher the redox potential the higher the electrostatic charge in mitochondria is present.   Recently, researchers at NC State have found that when a material incorporates atomically thin layers of water around a hydrophilic substance, it becomes able to store and deliver energy much more quickly in that system than if the same material didn’t include the water layers.  Pollack found the same thing in his water experiments with nafion, but neither team of researchers seem aware of each other findings.   This has some big implications for biology and for mitochondria, when you understand how charge works with mass and how it is quantized.

THE PHYSICS OF 'CHARGE' USED IN CELLS:

Electrostatic charging of mitochondria by sunlight is how life fundamentally works.  Forces between two electrically-charged objects can be extremely large. Most things in nature are electrically neutral; they have equal amounts of positive and negative charge.  Only a few charges can be moved around to create small scale charge imbalances because of the strength of the coulomb force.  I believe mitochondrial design is able to break the charge rule of symmetry so life can do the things it does.  Mitochondria concentrate positively charged H+ in their matrix and move 30 million volts of negative electric voltage across their inner mitochondrial membrane during respiration, all while they are creating water. Mitochondria are also moving "H+" from the matrix to the cytosol to make water, C02, and melantonin.

Heavy protons are too heavy and this effects bonding strengh which leads to less physiologic work (less ATP).   If  most things did not have a neutral charge, the world we live in would be a very strange place.  We also have a lot of control over how things get charged in biology.  The sun changes the electrostatic charge of our blood and water in our cells.  This is one reason why RBC’s have no mitochondria.  We need to maintain the neutral charge in blood until the light energy can be delivered from it, to mitochondria in tissues. If RBC's had mitochondria it would disrupt the ability to quantize charge in mammals.  This is likely why they do not have them.

When it comes to considering charge, materials on Earth are divided into three categories, depending on how easily they will allow charge (i.e., electrons) to flow along them. These are:

Conductors - metals

Semi-conductors - silicon in chips and life use hydrated carbon semiconductors

Insulators - rubber, wood, plastic

I bet you did not know water made in a mitochondria is a semiconductor.  Water always hydrates the other part of our semiconductors: protein.  This is why DNA only codes for protein.  Cells are semiconductor fabrication plants.  

Most materials are either conductors or insulators in cells and in nature. The difference between them is that in conductors, the outermost electrons in the atoms are so loosely bound to their atoms that they¹re free to travel around.  In insulators, on the other hand, the electrons are much more tightly bound to the atoms, and are not free to flow. Semi-conductors are a very useful intermediate class, not as conductive as metals but considerably more conductive than insulators. By adding certain impurities (doping) to semi-conductors in the appropriate concentrations the conductivity can be well-controlled.  Cells with collagen often use copper and phosphorus as a dopant.  This is why collagen cross links all have copper ions as a component and why the 'P' in ATP represents phosphorus.

There are three ways that objects can be given a net charge.

These are:

Charging by friction - this is useful for charging insulators/semiconductors. If you rub one material with another (say, a plastic ruler with a piece of paper towel), electrons have a tendency to be transferred from one material to the other. For example, rubbing glass with silk or saran wrap generally leaves the glass with a positive charge; rubbing PVC rod with fur generally gives the rod a negative charge.  Vortexing liquid crystals semiconductors also creates friction which can generate a charge that is quantized.  This is how water gains charge in the circulatory system via turbulent flow around the cells in blood plasma.

Charging by conduction - useful for charging metals and other conductors. If a charged object touches a conductor, some charge will be transferred between the object and the conductor, charging the conductor with the same sign as the charge on the object. RBC’s are conductors and can transfer their charge to water in blood plasma.  This is why EZ water develops a net negative charge when it forms.  Charge is being transferred.

Charging by induction - also useful for charging metals and other conductors. Again, a charged object is used, but this time it is only brought close to the conductor, and does not touch it.  This mimics how sunlight interacts with hemoglobin and chloroplasts in living systems in trapping light energy before it changes to an electric charge in EZ water.  To gain the charge best from sunlight you need to be grounded to Earth.   If the conductor is connected to ground (ground is basically anything neutral that can give up electrons to, or take electrons from, an object), electrons will either flow on to it or away from it. When the ground connection is removed , the conductor will have a charge opposite in sign to that of the charged object.  This is why being disconnected from Earth chronically leads to things like rouleux formation and clotting.  Since water molecules, are naturally polarized (magnetic dipole), they can quickly remove charge from a charged object.  This is why blood is 93% water by volume.  Mother Nature uses every last bit of physics the universe gives her to work with.

On sunny clear days with low humidity are associated with ionospheres with high electric fields, low magnetic fields and diminished energy transfer from the sun to us if we do not have a connection to Earth.  Why?  Electrostatic charges are not transferred well when water is not present.  This is why dehydration from a lack or water production in mitochondria favors illness. It is also why deuterium is not favored by living systems in nature.  It cannot transfer charge as well as light hydrogen can, because its extra mass affects bonding strengths in all molecules it is used in.  This is why life tries to exclude it. (kinetic isotope effect)

Dry air is a relatively good electrical insulator, so if something is charged, like clouds on a sunny day,  the charge tends to stay in th cloud where the water is. In more humid conditions, such as you find on a typical summer day in New Orleans, water molecules, which are polarized, can quickly remove charge from a charged object.  This is why the southeast has massive electrical storms.  It is also why humans can get massive benefits even in cloudy weather in the southeast but the same is not true in Seattle.  The humidity of the ionosphere does not allow charge transfer from the solar plasma to the ionosphere to out wetware carbon based semiconductors.

Your brain is filled with water next to your thalamus.  It is designed to sense this daily diurnal change of the Schuman resonance created by these electrical storms.

The NC State research findings on water raises some interesting questions about the behavior of liquids when confined at a small scale in a cell or inside a mitochondria.  It appear life took big advantage of this"sheet effect"  3.8 billion years ago when bacteria first showed up on Earth because it held promise for shaping future energy-storage technologies for cells who could take advantage of it.

When water is depleted of its atomic mass it helps to preserve stability of hydrogen bond networks in the coherent domains of water inside of cells, protecting against aneuploidy in chromosomes and resisting strand breaks in nucleic acids.  It also allows for optimized optical signaling within the cell to preserve the liquid crystaline structure inside the cell.  This can affect a persons ability to handle a stressed environment who is exposed to nnEMF radiation, blue light, and certain anticancer chemotherapeutics to improve survival as the video above shows.

Blood is designed to carry charge from the sun in quantized format to mitochondria for processing.  It does this for sunlight and it does it for food as well.  Food is broken down in the gut and carried to cells in lipid rafts that act as electric field sensors.  The food has its hydrogen stripped off and are broken down to electrons.  Allopathic medicine and functional medicine remain ignorant of how charge is quantized and how that effect is brought to bear massive effects in tissue to our mitochondrial colonies.  We have ten to the 14th mitochondrion in our cells.  This far outstrips the bacterial colonies we have in our gut.

SUMMARY:

Many people do not understand mass equivalence at the most fundamental levels.  All mass is a property that all energy is capable of exerting when the environment allows for it.  So when I have told my members that just turning a light on affects the mass of a flashlight, or standing next to the Great Pyramid of Giza can increase your longevity because of the secrets buried in E = mc^2 people laugh.  They laugh because they do not understand what Einstein's paper really means to living systems.  This becomes massively important to medicine because medical science is based upon biology.  So when a living thing exists it emits light at some level thereby losing some it its mass just like the sun does.  This is why I have commented many times that a mitochondrion and the sun have a lot in common.  When you consider that the colony of mitochondrion collect hydrogen atoms, and the goal of the first three cytochromes is to strip foods of the hydrogen atom via the three dehydrogenases we have and then the mitochondrion separates the electron from the proton in an hydrogen atom and stores the H+ proton in its matrix, you begin to understand there is a way deeper meaning to life with respect to energy thermodynamically.  Atomic mass effects charge and density and this affects the hydrogen wave function that is possible.  The charge transfer is quantized and it is related to the mass of the particle that carries the charge.

This is why medicine is missing the keys to restoring health to those with chronic diseases.  The water your mitochondria makes via metabolism is the key to health optimization, not the water you drink. Ketosis makes more water than glycolysis and that it is why it is a good tool to use in illness but that tool can devastate you when heteroplasmy rates in mitochondria are far too high.

The water our mitochondria makes from metabolism (gluconeogenesis and beta oxidation) is how eukaryotes brought the oceans inside their bodies to live on land.  The water you drink should be free of toxins like bromine and fluoride and not be polluted by man made things like metals, glyphosate, deuterium.  If it is you have a detox system in you built by the sun.  You'll learn more about that in time. This should be obvious now after this blog, Nature has a plan for us.  But structuring water outside the body is done by nature and it is why spring water is a great choice because that is what nature gives living things in the hydrology cycle.  

Realize that water we make inside of our cytosol is hit by sunlight frequencies that penetrate our cells only, and that light energy creates a zone that can exclude all things the size of a proton or greater. That is the key bio-physical change water needs inside of us to make life possible.  That physical change makes the entire cell a liquid crystal.  Liquid crystals have special quantum behaviors that are non linear.  This is the stage life is built upon.   The water you drink only affects the ECF in the body and not the cytosol in the cell.  The cytosol in your cell is a function of how good your mitochondria is working and this is directly linked to the redox state of the cell.   People conflate the two and it is a mistake in understanding of the bio-physics of life.

CITES:

https://news.ncsu.edu/2017/04/water-pseudocapacitors-2017/

https://www.ncbi.nlm.nih.gov/pubmed/26826644

https://www.nature.com/news/earth-has-water-older-than-the-sun-1.16011

https://www.nature.com/news/tiny-diamond-impurity-reveals-water-riches-of-deep-earth-1.14862

https://sci-hub.bz/https://doi.org/10.1016/j.jphotobiol.2017.04.014

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643261/

https://www.nature.com/news/common-source-for-earth-and-moon-water-1.12963

https://www.researchgate.net/publication/279965777_Light_Effect_on_Water_Viscosity_Implication_for_ATP_Biosynthesis

Retinal blood flow increases 40 to 70% after the transition from dark to light in the AM.  This increases blood flow which increases oxygen delivery to the deep retinal structures.  This reduces pseudohypoxia, raises NAD+, while improving the pulse creation of nitric oxide in the retina to improve the microcirculation.  Solar exposure of the retinal actually increases blood flow in the retina so that the entire blood volume in the circulatory system in 15-30 minutes.  This is why AM sunlight exposure is huge for wellness creation.

This also points out why wearing contacts, glasses, and sunglasses can be lead to disease and and an early death.  For those who think this is hyperbole, look at the page from John Ott's book called Health and Light, and read for yourself what Albert Schweitzer found in Africa when natives were given sunglasses.  Cancers began to manifest.  Instead of disbelieving this observation from 100 years ago, spend some time reading the new science recently published that show the precise mechanism of how this happens.  It is included in this blog. 

Emerging research is illuminating the dark side of wearing sunshades that links to hypoxia and photoreceptor damage. Sunglasses alter the solar frequencies to trick the brain by changing the solar frequency spectrum the eye senses into thinking it’s dark and prevent it from producing a hormone (melanin) using nitric oxide pulses that protects against sunburn, according to new research.

Tryptophan is an aromatic amino acid which make melatonin.  Tryptophan has to be programmed with UV/IR-A light to work properly in cells as I covered in the QT-14 blog on patreon and this picture below.

Tryptophan creates serotonin and melatonin and they are other key light mediated hormones.  serotonin affects behavior and mental abilities and melatonin controls energy production from mitochondria.  The melatonin hormone curbs the creation of the cancer state in cells when it is created in cells by UV and IR-A light from the sun.  This makes sunlight nature's vaccine for cancer.  Anything that destroys melatonin levels makes cancer much more likely possibility.  This is why poor sleep links to many bad diseases. 

So why in God's green Earth would anyone believe that suncreen or sunglasses are helpful to health when you know this PEER reviewed science since both lower our ability to make melatonin?  

PROFIT is the only logical answer.  

What is the science behind this claim?  Take a look at this paper via the HYPERLINK 

When we have an inhibition of the pineal function with pinealectomy or via the chronic exposure of our eyes and skin to blue light from technology, this light stimulus stimulates many cancers like, mammary cancers and skin cancers, , whereas blue light deprivation at night inhibits the carcinogenesis.  This is why I recommend blue blockers and clothing at night in artificially lit environments.   Epidemiological observations on increased risk of breast cancer in night shift workers, flight attendants, radio and telegraph operators and on decreased risk in blind women are in accordance with the results of experiments in rodents.

Treatment with pineal indole hormone melatonin inhibits carcinogenesis in pinealectomized rats or animals kept at the standard light/dark regimen (LD) or at the constant illumination (LL) regimen.  The physiology has been proven to happen in humans as well as the picture above illustrates. This is how many epithelial cancers like breast cancer and prostate cancer manifest.  In fact, most epithelial cancers come from altered light environments.  The proof is in the literature but no one in Big medicine and Big Pharma seem interested in the simple solutions I have been preaching for 1.5 decades now.  They want to keep everyone believing drugs and surgery remain the best idea for treating cancer.  It is impossible to patent sunlight, so this Rx is never presribed.  In fact, the sun has been vilified to drive profits from illness. 

When melanopsin damage occurs, vitamin A is liberated and this destroys the photoreceptors in the body that cause disease.  

UV light in the eye activates a chemical known as the melanocyte-stimulating hormone which makes the skin thicken and go brown to protect it from harmful rays.
Sunglasses block UV light from entering the pineal gland through the optic nerves in the eyes via the central retinal pathway I spoke about in my Vermont 2017 talk above. 

This prevents the brain from sending the signal to the pituitary gland to produce melanin, the pigment that tans the skin and protects it from burning. Excess Vitamin A in the blood also causes a reduction of melanin and lowers its photochemical abilities. This is why blue light and melanopsin dysfunction have been linked to many cancers. This was initially covered in ophthalmologist Fritz Hollwich's work from the 1940s as well. Also covered by Ott and Albert Schweitzer as seen below.

Here is the study below on sunglasses you might want to have a review before continuing your beliefs that they help you build wellness.   This belief is UNWISE in my opinion.  

Ultraviolet B Irradiation of the Eye Activates a Nitric Oxide-dependent Hypothalamopituitary Proopiomelanocortin Pathway and Modulates Functions of α-Melanocyte-stimulating Hormone-responsive Cells

This study clearly shows that localized UVB irradiation of the eye activates the hypothalamopituitary proopiomelanocortin (POMC) system via the iNOS-dependent neuronal network involving the first branch of the trigeminal nerves passing through the ciliary ganglia (parasympathetic ganglion located just behind the eye); therefore α-MSH-receptor containing cells are stimulated, such as DOPA-positive melanocytes in the skin. Given the high mutagenic activity of UVB, stimulation of the proliferation of, and of the synthesis of melanin pigments by epidermal melanocytes might play important parts in the protection of the underlying cells against UVB toxicity (Luger et al, 1998). Thus, the signaling pathway activated by UVB irradiation of the eye to increase plasma levels of α-MSH might function as ultra-sensitive mechanism by which UVB toxicity could be minimized in animals living in UV-enriched environment.

POMC (pictured above) is cut (cleaved) to give rise to multiple peptide hormones. Each of these peptides is packaged in large dense-core vesicles that are released from the cells by exocytosis in response to appropriate stimulation:

• α-MSH produced by neurons in the ventromedial nucleus has important roles in the regulation of appetite (POMC neuron stimulation results in satiety.) and sexual behavior, while α-MSH secreted from the intermediate lobe of the pituitary regulates the movement of melanin produced from melanocytes in skin.  This hormone is linked to the obesity epidemic humans currently face.  It also links it to infertility, and gender identity issues so common now.
• ACTH is a peptide hormone that regulates the secretion of glucocorticoids from the adrenal cortex.  This links to disorders linked to adrenal collapse like CFS/ME and Lyme and mold disease as well as electromagnetic hypersensitivity.
• β-Endorphin and [Met]enkephalin are endogenous opioid peptides with widespread actions in the brain.  This is where the current opiate crisis came from.  

WHAT WILL THE WISE NOW REALIZE?  

DON'T WEAR SUNGLASSES WHEN OUTSIDE! 

UVB is a needed part of the sun = MORE alpha-MSH = LESS DISEASE

The key point for the wise to realize is that solar UVB light is never present without IR-A and it is only present at certain precise times of the day tied to your location on the planet when blue light also has a specific color temperature that varies.  Using UV light without these boundary protective frequencies will always show a problem in the research.  This has benefited the dermatology and ophthalmology profits because it drives both eye disease and skin disease when you bury UV light from the sun from your life.  That is how the game is now played.  

UVB irradiation of the eye causes a positive local inflammation by stimulating nitric oxide (NO) to be produced as well as other inflammatory mediators from the vessels in the eye. This signaling molecule travels through the ciliary ganglia (parasympathetic ganglion located just behind the eye), which is the associated ganglia of the trigeminal nerve. This in turn activates the hypothalamopituitary proopiomelanocortin (POMC) system to do its thing in the eye and the central retinal pathways.

What is the above slide really saying? It says when UV light is present from the sun, Nature always wants Near infrared A  light there to replace the energy production in ATP function in the 600-1000nm range.  Sunlight always has this recipe.  UV light is NEVER found without NIR in Nature.  This is why this mechanism is built as it is.  It is also why use of UV light alone needs to be put in context.  

αlpha-Melanocyte-stimulating hormone (a-MSH) is cleaved from pro-opiomelanocortin (POMC) in the pituitary. Note: humans the skin is a more important source of the peptide. Skin pigmentation is therefore regulated by locally produced alpha-MSH rather than that of pituitary origin. Blue light stimulate alpha MSH more than any color in the visible spectrum.  This is why blue light is linked with obesity, cancer, and mitochondrial damage.  a-MSH is released into the plasma and DOPA positive melanocytes in the skin are stimulated.

Thus UVB radiation of the cornea and iris (UVB has weak penetration so does not readily pass to the retinal or beyond), may confers many down-stream benefits in tissues, beyond melanin production in melanocytes, via a-MSH. The proof that small amounts of UVB radiation does penetrate the anterior chamber of the eye is in the picture below.  This is not well known by most physicians globally.  They are taught that the anterior chamber blocks all UV light.  In 2009 when we found a UVA receptor called neuropsin on the cornea/skin this should have stimulated physicians to question these old beliefs but it has not.   

• Protection against UV-mediated DNA damage and the onset of oncogenesis is afforded by the tanning response in which UV irradiation triggers melanocytes to increase production of melanin that is then transferred to keratinocytes. Blue light does not stimulate melanin while UV does, and this is why blue light is associated with epithelial cancers and UV light is not.  The literature has missed this nuance.  A key component of the tanning process is the UV-mediated induction of the pro-opiomelanocortin (POMC) and MC1R genes encoding the alpha-melanocyte-stimulating hormone
• UV light decreases appetite/increases satiety = Leptin Rx
• Stimulates production of β-Endorphin and endogenous opioid peptides = reduces pain
• Better regulation of adrenal glucocorticoid hormones = lowers blood glucose
• α-MSH modulates the expression of Nrf2 and Nrf-dependent genes as a novel cytoprotective effector mechanism of this hormone. = decreases inflammation
• α-MSH suppresses TGF-β1-induced collagen synthesis by human dermal fibroblasts. transforming growth factor-β1 (TGF-β1),1 a multifunctional cytokine, is crucially involved in the pathogenesis of fibrotic disorders such as hypertrophic scars, keloids, localized scleroderma, systemic sclerosis, sclerodermic graft versus host disease of the skin, cirrhosis of the liver, and idiopathic induced lung fibrosis.  Red light augments these effects.
• 

• alpha-MSH has potent protective and antiinflammatory effects. At the molecular level, alpha-MSH affects various pathways implicated in regulation of inflammation and protection, i.e., nuclear factor-kappaB activation, expression of adhesion molecules and chemokine receptors, production of proinflammatory cytokines and mediators, IL-10 synthesis, T cell proliferation and activity, inflammatory cell migration, expression of antioxidative enzymes, and apoptosis.
• Realize that that Cold Thermogenesis 4-6 blogs all explain how alpha MSH links to leptin.  Leptin biology in turn operates via the central retinal pathways to be distributed all over the central nervous system to communicate energy balance throughout 
• The picture below should be self explanatory how many collateral effects are possible by wearing any tarps over your eyes.  Destruction of these photoreceptors lead to many diseases in modern humans.

SUMMARY:

Never cover your eyes from the sunlight they evolved to detect and regulate your hormones from sunrise to sunset. Diurnal animals also need darkness after sunset to release melatonin. Do cover your eyes and skin from artificial light at night? 

If not this is worse than wearing sunglasses during the day and why I recommend great blue blockers!  

Oxygen sensing by arterial chemoreceptors WHOLLY depends on mitochondrial complex I signaling = NAD+ levels.  

Sunglasses make the brain think it’s dark and this means you’re not starting the natural process of tanning.

As a result, you’re more likely to burn and therefore at more risk of skin cancer.  Light in the eye is an important factor in health.  the wrong frequency of light at the wrong time of day/night helps to short-circuit the body’s natural innate and adaptive defense mechanism against the sun.

It also puts you at risk for viral infections like C-19.  Imagine that.  

Light sculpts your life.  And sunglasses might be one of the key ways we get cancer.  A simple behavioral change might save your life.  How is it chiseling your marble today?

CITES:

https:. //www.sciencedirect.com/science/article/pii/S0022202X15301160

https://www.sciencedirect.com/science/article/pii/S1550413115004611

https://www.nature.com/articles/nature04284

https://iovs.arvojournals.org/article.aspx?articleid=2176699

How do eukaryotic cells make light from matter? It all begins with the fact that oxygen is the terminal electron acceptor for eukaryotes mitochindria. The oxygen molecule O2 displays some very particular features. It is a paramagnetic gas. It is the second most electronegative element in the periodic table. Because of this one should expect that O2 is a very reactive chemical compound. Counterintuitively, however, it is a quite unreactive molecule on Earth. How can I say this? . A testimony to this is the decentralized fact that we live in a planet with a 21% oxygen atmospheric content, and nevertheless life thrives and even depends on it.

The reason why O2 is so much unreactive than we expect this atom to be, in spite of its electronegativity, is the fact that in the fundamental state it assumes a triplet electronic configuration. Triplet electronic configuration occurs when the valence electrons arrange in the O2 molecule has the electronic configuration with the least energy. According to the molecular orbital theory, this arrangement has a triplet character. Triplet character occurs when the two outermost electrons in oxygen have different antibonding orbitals, but with the same spin state.

3^O2 expresses the triplet character of the ground state. This ground state has a biradical chemical character, which renders it quite unreactive to most chemical compounds. This triplet character of oxygen makes ground state O2 a paramagnetic compound, where oxygen gas tends to move to the point of strongest magnetic field. This is why oxygen is drawn to your colonies of mitochondria. Mitochondria create a magnetic field because they have electron movements along its innermitochondrial membrane while having a spinning ATPase on that same membrane. This makes all mitochondrial respiation electromagnetic at the most fundmental level.

Implications of this for cells? The cell cycle is controlled by light creation in cells.

The metabolic rate in our mitochondria drives developmental timing by controlling the cell cycle.

Having light stored at the electronic level is critical to the mystery of morphogenesis.

Back at the origin of life 3.8 billion years ago on Earth electric membranes drove CO2 fixation by converting gases from volcanoes (driven by the solar plasma) into organic chemicals to create growth in the absence of oxygen. This was the first step life took at the ocean floors.

Metabolism has always been spontaneous on Earth. Today, we believe complex life emerged from ancient autotrophic pathways fueled by volcanic gases as carbon and the sun as ultimate energy sources. Variants of these pathways remain in modern autotrophs in the deepest branches of the tree of life. In this way, the DC electric current in membranes preceded all chemistry. The energy metabolism of modern autotrophs resembles the geological interactions of H2 and CO2 gases in hydrothermal vents. Centralized science believes this points to a metabolic origin of biochemistry at the interface of the lithosphere and hydrosphere. Decentralized science believes this points to a quantum thermodynamics at the core of life because the sun drives all these processes. This step is fundamentally why light tops food in all my discussions.

Reactive oxygen species (ROS) are formed during normal metabolic processes. Mitochondrial respiration is spontaneous on Earth. Genes amplify metabolism and in this way, gene products are capable of making more or less light from how they amplify or de-amplify metabolic networks in cells.

ROS are magnetic signal created from excess oxygen in mtDNA. People forget molecular oxygen is the only paramagnetic gas on the periodic table. This makes it a unique magnetic signal used in cellular communication. All free radicals have one unpaired electron to make them magnetic sugnals. All ROS are called singlet oxygen signals that come from mtDNA actions. When electrons are added to a magnetic molecule this is called a reduction type of reaction. When singlet oxygen is reduced by the addition of electrons, the ROS magnetic signal shifts to a lower energy state and as a result emits photon.

The electronic transition of electronically excited species from the singlet or the triplet excited state to the ground state is accompanied by photon emission. This is how light is crerated by life. In this mechanism only a few photons are emitted per second per square centimeter, the photon emission is ultra-weak in nature. But it is these photons that explain how light sculpts life.

Reactive oxygen species are formed during the metabolic processes linked to life-sustaining enzyme-catalyzing reactions. They also can be formed during the response to stress reactions when any life form is exposed to biotic and abiotic stress factors from our environment. When ROS are effectively scavenged by the antioxidant defense system, the oxidative effect of ROS on biomolecules such as lipids, proteins and nucleic acids is fully prevented.

HOW IS ENDOGENOUS LIGHT CREATED? 

Cells cannot product light without oxygen or ROS/RNS made in mitochondria. Mitochondria are not only time machones, they are factoried for biophotons. That is the bare minimum and is confirmed in Roeland Van Wijk book on the topic of biophotons. During the process of cellular respiration, electrons are transported through a series of mitochondrial complexes to the terminal electron acceptor, molecular oxygen (O2). In the process of cellular metabolism, the electrons released from the ETC react with O2 to produce superoxide (O−2) radicals. Mitochondrial complexes I, II, and III contribute to the maximum in redox signaling. Superoxide radicals generated at complexes I and III are released into the intermembrane space which comprises 80% of superoxide radicals generated in the mitochondria and remaining 20% are made by mitochondrial matrix.  The mitochondrial permeability transition pore in the outer membrane of the mitochondrion allows the passage of superoxide radicals into the cytoplasm where it is dismutated to hydrogen peroxide, a highly diffusible secondary messenger. This reaction is catalyzed by superoxide dismutase located in the mitochondrial matrix (MnSOD) or in the cytosol (by Cu/ZnSOD).  

Furthermore, aquaporin 8 serves a channel for the release of hydrogen peroxide from the cell membranes.  There is an another major site for the generation of ROS termed as peroxisomes where superoxide and H2O2 are generated through xanthine oxidase in the peroxisomal matrix and membranes. Other sources of ROS include endogenous metabolites such as fatty acids, prostaglandins, and exogenous components including drugs, flavorings, coloring agents, antioxidants, etc. These substances are processed in the smooth endoplasmic reticulum and transformed into free radicals, especially ·OH. Macrophages and leucocytes, as a part of immune response contribute to the formation of free radicals

SO NOW YOU KNOW HOW ROS ARE MADE, HOW DO THEY TRANSFORM MATTER TO EMIT LIGHT?

However, under circumstance, when the formation of ROS exceeds the capacity of antioxidant defense system, biomolecules in cells spins are changed by magnetic forces in mitochondria. The single unpaired electron of ROS oxidizes lipids, proteins in both nuclear genome and mitochondrial nucleic acids. This interaction leads to the formation of high-energy intermediates like singlet oxygen. The decomposition of high-energy intermediates generates the electronically excited species which undergo an electronic transition from either the singlet or the triplet excited state to the singlet ground state. When there is an electronic transition of electron spin light is liberated.

When electron spin is changed, & our biomolecules are changed and the result in matter in our cells is to liberate light.   

Singlet oxygen, systematically named dioxygen and dioxidene, is a gaseous chemical with the formula O=O, which is in a quantum state where all electrons are spin paired. It is kinetically unstable at ambient temperature in cells, and its rate of decay is slow.

Singlet oxygen (represented as 1ΔgO2, abbreviated as 1O2 in papers) is not a radical but represents an excited state of O2 in which the spin of one of the unpaired electrons is changed to yield two electrons with opposite spins. The terms 'singlet oxygen' and 'triplet oxygen' derive from each form's number of electron spins. The singlet has only one possible arrangement of electron spins with a total quantum spin state of 0, while the triplet state has three possible arrangements of electron spins with a total quantum spin of 1, corresponding to three degenerate states. An excellent way to detect the presence of singlet oxygen in reactions is using steady-state or time-resolved measurements to find its characteristic phosphorescence at around 1270 nm.

When oxygen is reduced by losing an electron, singlet oxygen is created chemically. Singlet oxygen is an reactive oxygen species (ROS). The loss of the electron shifts the biomolecule to a lower energy state and as a result it emits photon. RNS works exactly the same way. This is how mitochondrion make light from matter.

The oxidation of biomolecules occurs by hydrogen abstraction by superoxide anion and hydroxyl radicals or by the cycloaddition of singlet oxygen initiate a cascade of oxidative reactions that lead to the formation of electronically excited species such as triplet excited carbonyl, excited pigments and singlet oxygen. The abstraction of hydrogen is defined by the removal of a hydrogen atom or group from a molecule by a free radical. Hydrogen/deuterium atom abstraction is often confused with deprotonation, which is the removal of a hydrogen atom (i.e., a proton) by a base in an acid-base (proton transfer) reaction.

When deuterium is abstracted out by light cells need to use more UV light to do so because you need more VUV-UVC-UVB-UVA light to abstracted the heavier isotope of hydrogen because of the extra neutron. Generally, the way oocyte selection occurs in mammals is by hydrogen abstraction. The oocytes with the lowest atomic mass are ejected first. during menarche. As time elapses, the eggs with the most deuterium and released last because more light is needed to get that job done. This drains the electronic level of its stored light.

This means the older a pregnancy becomes the more light is needed in the transgenerational process. In this way you can see now why high maternal age and transgenerational epigenetic diseases occur. It is also why more chromosomal abnormalities occur as mammals age. If the UV light is expended abstracting deuterium there is less light left at the elctronic level to drive the cell cycle past the mitosis level. This is a huge problem in infertility, cancer, and in morphogenesis (autism)

The photon emission of these electronically excited species is in the following regions of the spectrum (1) triplet excited carbonyl in the near UVA and blue–green areas (350–550 nm), (2) singlet and triplet excited pigments in the green–red (550–750 nm) and red-near IR (750–1000 nm) areas, respectively and (3) singlet oxygen in the red (634 and 703 nm) and near IR (1270 nm) areas. The understanding of the role of ROS in photon emission allows us to use the spontaneous and stress-induced ultra-weak photon emission as a non-invasive tool for monitoring of the oxidative metabolic processes and the oxidative stress reactions in biological systems in vivo, respectively.

Transcriptional regulation of proteins is done by GLUT expression by ROS in cells.

Since ROS is made from excess dissolved oxygen not used in mitochondria, when oxygen in cells decreases, ROS signaling becomes more unique because of scarcity. This should make you think about my Kruse for Dummies lecture.

Low oxygen triggers signal-transduction pathways involved in both cell death and survival. Anoxia activates proapoptotic BCL-2 proteins and caspases to initiate apoptosis. The adaptive cellular events that occur in response to hypoxia are mediated largely by the transcription factor hypoxia-inducible factor-1 (HIF-1)

During hypoxia, ROS levels increase by design and play an important role in HIF-1α stabilization. HIF-1 consists of two subunits, HIF-1α and HIF-1β. Under normoxic conditions, prolines within the oxygen-dependent degradation domains (ODDs) of HIF-1α are hydroxylated by prolyl-4-hydroxylases (PHDs; Ivan et al. 2001). This hydroxylation mechanism acts as an ubiquitination signal leading to proteasomal degradation of HIF-1α. In the absence of oxygen, HIF-1α ubiquitinylation is inhibited allowing its interaction with HIF-1β to drive transcription of various target genes, including GLUT1. This is the basis of how the Warburg shift occurs in humans.

Stimulation of cellular glucose uptake in mammalian cells is frequently observed during conditions of oxidative stress when ROS and RNS spikes. GLUT1 helps in the transport of glucose, galactose, mannose, glucosamine and ascorbic acid in mammals.

HIF-1 induces the expression of multiple antiapoptotic BCL-2 proteins to promote cell survival. Interestingly hypoxia increases production of mitochondrial reactive oxygen species (ROS), which serve as signaling molecules to activate HIF-1.

Hypoxia-inducible factors (HIFs), are major molecules that respond to hypoxia and elevated temperatures to play important roles in cancer development by participating in multiple processes. HIF1 is linked to circadian clock controls, metabolism, proliferation, and angiogenesis. The Warburg phenomenon reflects a pseudo-hypoxic state that activates HIF-1α. In addition, a product of the Warburg effect, lactate, also induces HIF-1α. However, Warburg proposed that aerobic glycolysis occurs due to a defect in mitochondria. I believe the defect occurs, first, in the circadian mechanism to affect mitochondrial metabolism. Moreover, both HIFs and mitochondrial dysfunction can lead to complex reprogramming of energy metabolism, including reduced mitochondrial oxidative metabolism, increased glucose uptake, and enhanced anaerobic glycolysis

HOW DOES HYPOXIA LINK TO ALTERED TIME STAMPING IN CELLS?

Circadian clocks are endogenous coordinators of the 24-hour rhythm of behavioral and molecular processes in living organisms. For humans, a master clock modulating circadian rhythms is located in the suprachiasmatic nucleus of the hypothalamus and is a pacemaker of the system. In mammals, the circadian clock is comprised of a set of genes, which function as activators—CLOCK and BMAL, which, similarly to HIF, are bHLH-PAS transcription factors.

HIF-1α GENE HAS A TRANSCRIPTION REGULATORY ELEMENT TO ALTER THE CIRCAIDAN CLOCK MECHANISMS. THIS IS HOW DIESESE ARE CAUSED IN THE MODERN WORLD.

Through binding to regulatory elements containing E-boxes (also present in HIF-1α gene) they activate the transcription of repressor protein period (PER) and cryptochrome (CRY). Additionally, HIF can bind to promoter regions of repressor proteins through hypoxia response elements (HRE), causing their transcrioptional upregulation leading to altered cell signaling. This is how the redox shift leads to alien light creation to lead to genetic changes we see in ALL CANCERS.

It is believed in centralized science that mitchondrial ROS oxidizes lipids, proteins and nucleic acids and thus initiate a cascade reactions that leads to the formation of electronically excited species responsible for the photon emission in near UVA, visible and near IR regions of the spectrum. I think this is a simple explanation for what is really going at the atomic level in a cell.

To make it crystal clear how bad the advice centralized medicine is giving patients you just need to review this thread in the context of what is being clearly laid out in this blog. Read this thread below in blue before going on.

https://threadreaderapp.com/thread/1754147699799040292

COVID AMPLIFIES THIS SCIENCE FOR THE SLEEPING SO THEY WAKE UP WHERE MODERN DISEASES COME FROM

TURBO CANCERS, mRNA, SV40, CIRCADIAN MISMATCH LINKS TO BIOPHOTONS

p53 is an important tumor suppressor gene, found to be mutated or absent in over 50% of all cancers studied. It functions as a sequence-specific DNA-binding transcription factor. In response to double-stranded DNA breaks, p53 is converted from a latent to an active form. This results in increased expression of p53-responsive proteins such as p21 which are required for growth arrest at the G1-to-S phase transition. It also mediates apoptosis via the increased expression of proteins such as Bax. Inactivation of p53, therefore, results in the loss of a cell cycle checkpoint control required for repair of damaged DNA and prevents apoptosis in response to severe DNA damage. In the absence of these responses, oncogenic mutations which may result in tumor progression can accumulate in nuclear DNA and this can happen quickly in people who took the mRNA jab. The damage can accumulate rapidly. From the above, it is clear that the transcriptional activation function of p53 is critical to its role as a tumor suppressor gene. Since genes amplify metabolic networks, p53 clearly clearly has a lot to do with the biophoton spectra that cells emit.

Note the history of the discovery of p53 brings us back to the story of SV40 and the polio vaccine. That is why Pfizer erased it from their plasmid map in the mRNA platform.  Simian virus 40 (SV40) large tumor antigen (T antigen) has been shown to inhibit p53-dependent transcription by preventing p53 from binding to its cognate cis element.

 Why is p53 called p53?

One must know the history and the discovery of the most studied gene in human history, also known as the guardian of the genome.  Why is it considered the guardian of the genome?  Aneuploidy refers to the state of unequal chromosome copy numbers and is one of the most prominent genomic aberrations in solid tumors.  Most solid tumors are aneuploid, and p53 has been implicated as the guardian of the euploid genome. 

How long did the pulse of cancer stay in human cancer data from the Cutter incident of the Polio vaccines?

Bernice Eddy found the SV40 in the Salk vaccine and told the world about it in th emid 1950s'  The NIH and FDA ruined her career over her admission and scrubbed their websites.  Most people ran from studying SV40 after this event in centralized science until the Nixon administration. What cancers in humans are linked to SV40 contamination?

In the 1970s, David Lane & Arnie Levine started studying a virus called SV40. Their interest was in a viral gene responsible for transformation, the SV40 oncogene called large T antigen.  Lane's task was to extract the large T antigen protein from cells infected with SV40. He used electrophoresis to separate the protein molecules based on size and charge.  Whenever he ran electrophoresis to purify the large T antigen, he always found an unknown protein with a molecular weight of 53 kilodaltons. Initially, others in Lane's lab thought it was a contaminant or a breakdown product of the large T antigen.  As reports of this protein came from other labs too, it was named p53 based on its molecular weight.

In 1979, immunological studies identified the p53 protein due to its immunoreactivity with tumor antisera, suggesting its role as a tumor-associated antigen. Everyone was convinced they had found a new oncogene. The excitement was high!  Wait a minute—did I say oncogene? p53 is actually a tumor suppressor gene! This is my favorite plot-twist of the p53 story: its mischaracterization as an oncogene.  The initial misclassification was due to the research climate of the time (1980s). Oncogenes were thought to be the key to understanding cancer, and the idea of a tumor suppressor gene was in its infancy.  

As mentioned above, p53 was initially found bound to the major oncogenic protein of SV40, so it was understandable at the time to think it must be an oncogene as well. However, some experimental observations did not fit well with the idea that p53 was an oncogene.  In 1986, the first tumor suppressor gene, Retinoblastoma gene (RB1), was discovered, confirming Knudson's Two-Hit hypothesis.  In 1989, this two-hit model was applied to p53, specifically in colorectal tumors. It fit this model, as in virtually all cases, both copies of p53 were mutated.  

This conclusion was confirmed by subsequent findings that patients with inherited mutations of p53 were predisposed to diverse tumor types. Mice with engineered "knock-outs" of the p53 gene were also tumor-prone.  Today, more than 70,000 research papers are published on p53, making it the most studied human gene in history. Mutations in p53 are found in >50% of human cancers.  "It's impossible or very difficult to get a malignant tumor without the activity of p53 being disrupted." ~Bert Vogelstein, a legendary figure in p53 story who was the first to termed it as a tumor suppressor gene.  

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855935/

SUMMARY

New centralized data does not support a role for p53 in aneuploidy surveillance in organotypic cultures. There is strong evidence indicating that the loss of p53 is associated with chromosome instability and poor prognosis in the development of several cancers. See the papers (Donehower et al., 2019; Foijer et al., 2014; Fujiwara et al., 2005; Watson and Elledge, 2017)

When p53 goes awry the majority of tumors show varied TP53 mutations based on the following papers: (Clausen et al., 1998; Muller and Vousden, 2013). Live-cell imaging of Trp53+/+ and Trp53 & mCOs showed that mitotic errors, including lagging chromosomes and multipolar mitoses, occurred frequently in cells lacking p53, consistent with several published studies (Artegiani et al., 2020; Drost et al., 2015).

The bottom line issue for me? Decentralized science must show that when p53 signaling goes awry, it corresponds to a lack of ultraweak -UV biophoton production at the mtDNA level. This is why apoptosis goes awry and this also corresponds to the following variables: Low mtDNA melatonin production, low mtDNA water production, and altered mtDNA CO2 production in most solid tumors. This results in cell cycle arrest and cells begin to migrate to other tissues that have the ability to generate the ultra weak UV biophotons to complete the cell cycle.

CITES

1. https://www.pnas.org/doi/full/10.1073/pnas.1431692100

2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208645/

3.  https://x.com/DrJackKruse/status/1804162237528998309

4. https://x.com/DrJackKruse/status/1803877114598314228

Our tissues glow because when an electron is delocalized light is given off and that light produces change without atomic change because it changes the topologic charge of atoms in our skin proteins because UV light causes a loss of electrons in out tissues.  This mechanism is what causes release nitric oxide from the arterioles in our skin to change the topology or femtochemistry of the surface of the skin when it is irradiated by IRA and UVA light.  The change in femtochemistry results in attochemical changes in deuterium in our blood plasma.  

Full spectrum sun contain UVA/B light which is capable of altering the topologic charge of nitric oxide (NO).  

UVA light releases the most NO into our blood.  IRA light is how the exclusion zone is built initially in sunlight in our plasma.  Both of these frequencies penetrate below the epidermis to where the arterioles of our skin.  

The key thing to comprehend is there is no way to satisfy the octet rule for both atoms in NO because of their valence shell electron state. The structure is a double bond with three non-bonding electrons on N and four on O but really one of the electrons on N is not localized to N but the entire molecule.

Formal charge = electrons in ground state - (non-bonding electrons + 0.5 * bonding electrons)

Formal charge for N = 5 - ( 3 + 4 * 0.5) = 0 (there are two bonds so four electrons are involved in bonding)

Formal charge for O = 6 - (4+ 4 * 0.5) = 0

Sunlight alters that balance of charge on our surfaces.  What does it do?

It creates the triplet state of free radicals because of the effect on electron quantum spin.  Every surface in our body has this mechanism available if the sun is allowed to interact with it.  If the sun is absent this will not occur and it will lead to collateral damages.   Where else is electron spin altered?   MITOCHONDRIA.  This is where the critical ROS and RNS signals are made.  These signals affect a third cycle in us that controls the sulfated amino acids.  This is the sulfated amino acid cycle contains cysteine methionine and homocysteine.  This cycle is altered because of the changes in free radical creation by the light our skin does or does not experience.  

Full spectrum solar exposure of the skin increases sulfhydryl groups in the blood plasma.  This increases the anions present in our blood.  Sulfur amino acids are a kind of amino acids which contain sulfhydryl groups, and they play a crucial role in protein structure, metabolism, immunity, and oxidation. Recent studies have demonstrated the oxidation resistance effect of methionine and cysteine, two of the most representative sulfur amino acids, and their metabolites. 

Methionine and cysteine are extremely sensitive to almost all forms of reactive oxygen species MADE IN THE MATRIX, which makes them antioxidative and critical redox switchs that tell us about TCA and urea cycle kinetics.  They can both be used to tell us when the matrix is slowed by deuteration.  

Moreover, methionine and cysteine are precursors of S-adenosylmethionine, hydrogen sulfide, taurine, homocysteine,  and glutathione. These products are reported to alleviate oxidant stress induced by various oxidants and protect the tissue from the damage. However, the deficiency and excess of methionine and cysteine in our diet can affect the normal growth and longevity of animals. 

It is well known that oxidation from free radicals of the cysteine thiol groups occurs in all stressors in humans.  This results in defective glucocorticoid receptor (GR in pic above)  function and it affect ligand and DNA binding in cells.  This implies that in a 5G world where the toplogy of the skin will be affected, cysteine and methionine hacks will be quite important to understand and use when one gets afflicted with electropollution type diseases like autoimmunity, sepsis, and cancer.   To understand how these sulfated amino acids operate you must understand how the sun works in your skin.  I discussed this in the Vermont 2018 talk now available for purchase to Patrons and the public.

Vitamin D3 supplement pills don't and can never give you triplet state being described here because you need the light stimulus on the skin to get it.  You also need skin in the game to generate the light pressure on your skin and arterioles to enable the chiral effect.   Sunlight exposure of the skin, works in unison to sulfates the cholesterol anion substrates in the skin and blood from the sulfated amino acids so that cholesterol can become Vitamin D3 via various steps between the skin, kidney and liver under the power of UVA and UVB light.

KEY POINT ALERT:

UVA light helps in performing this task because of the action of activated NO in the skin.  NO inactivates cytochrome 4 while IRA light allows the ATPase to spin freely with fewer electrons needed from foods/fat due to the action of NO on ECT.  UVA light inhibits or slows electron chain transport flow on the inner mitochondrial membrane.   With this knowledge are you still afraid of black lights indoors?  You should not be.  It might be a great hack for you depending upon your N = 1 context.

Nitric oxide (nitrogen oxide, nitrogen monoxide) is a molecular, chemical compound with a chemical formula of NO that is a colorless gas under standard conditions. Nitric oxide is a free radical—i.e., its bonding structure includes an unpaired electron with a specific electronic spin state. It is a practically important intermediate in the chemical industry. In addition, some are unavoidably produced during combustion of fossil fuels in power plants and automobile engines, with an excess of NO being created when there is present more air or higher temperatures than needed for efficient and complete combustion of the fuel. More oxygen and higher temperatures in a cell favor H+ bonding. 

They lower deuterium bonding in the skin.  This is very important because it is the key mechanism of how and why deuterium is found in the high concentration of the blood plasma in the irradiated skin by the sun.  In skin thermal temps are raised most by UV/IR light and oxygen is increased by UV light striking the skin alone. 

Not only does skin make it with the powerful sun but so does the atmosphere in a quantum fashion. It is also produced naturally by the extremely high air temperatures produced along the path of lightning in thunderstorms.

Now stop here.  Did I not tell you in the past on previous blogs that the inner mitochondrial membrane can generate the same voltage as a bolt of lightning in the "What powers life and death blog years ago?"  Yep. 

30 million volts is possible. 

It was found that NO acts through the stimulation of the soluble guanylate cyclase, which is a heterodimeric enzyme with subsequent formation of cyclic-GMP. Cyclic-GMP activates protein kinase G, which causes reuptake of Ca2+ and lowers the intracellular calcium by the opening of calcium-activated potassium channels. This is highly protective in high nnEMF environments. 5G will block this effect in the skin. 5G will also destroy the covalent bond between melanopsin and Vitamin A.  This will demolish the entire circadian mechanism in all the peripheral clock genes.  

This is why 5G risks will ramp up mitochondrial diseases linked to the melanopsin/retinol system.  Melanopsin also uses calcium as a secondary messenger.  This creates another risk of nnEMF in destruction of the melanopsin mechanism.  nnEMF alters calcium flows and this is the signal that makes free radicals in the matrix for proper quantized signaling.

The fall in concentration of Ca2+ ensures that the myosin light-chain kinase (MLCK) can no longer phosphorylate the myosin molecule, thereby stopping the cross-bridge cycle and leading to relaxation of the smooth muscle cell in our skin arterioles allowing more RBC's loaded with porphyrins to continue absorbing UVA light to keep this action of NO working properly to keep deuterium inside of our arteries where it belongs.  Deuterium concentration in the blood plasma is how the body normally creates ELF-UV within our blood plasma to activate cell water to become an exclusion zone.  This is a topologic charge effect that must occur endogenously.

Nitric oxide, is also known as the 'endothelium-derived relaxing factor', or 'EDRF', is biosynthesized endogenously from L-arginine (urea cycle), oxygen, and NADPH by various nitric oxide synthase (NOS) enzymes. Reduction of inorganic nitrate may also serve to make nitric oxide in our gut. The endothelium of blood vessels uses nitric oxide to signal the surrounding smooth muscle to relax, thus resulting in vasodilation and increasing blood flow so we can collect a lot of UV light from skin irradiation. How does hemoglobin fit into this blood UV story?

Two important biological reaction mechanisms of nitric oxide are S-nitrosation of thiols and nitrosylation of transition metal ions. S-nitrosation involves the (reversible) conversion of thiol groups, including cysteine residues in proteins, to form S-nitrosothiols (RSNOs). S-Nitrosation is a mechanism for dynamic, post-translational regulation of most or all major classes of protein in all living things. This is why the ubiquitination series has so many blogs and threw so many new details at you.  They were foundational for this blog. 

Sunlight controls protein turnover via ubiquitin marking and nitrogen flow in cells using this mechanism.  Methionine is needed for this step no matter the protein being made by a cell.  The second mechanism, nitrosylation, involves the binding of NO to a transition metal ion like iron or copper in your cells.  In CPC #25 you saw how this process is broken in sepsis.   

Methylene blue, IV Vitamin C, and glucocorticoids in low doses can improve the function of sulfated amino acids in people with mitochondrial damage who do not get enough sunlight.  The sulfated amino acids are the critical optical switches in many neurotransmitter and glucocorticoid receptors.  They are also critical in DNA function.  This has been shown in many diseases like sepsis in many papers on PubMed.  Sulfur and iron clusters are found in the mouth of every cytochrome protein. Did you also know that cytochrome C oxidase is also a heme protein that has 4 red light chromophores embedded in its atomic structure?   This is why IRA light exposure is a critical part of solar exposure and control of apoptosis. 

In this nitrosylation function, NO is referred to as a nitrosyl ligand. Typical cases involve the nitrosylation of heme proteins like cytochromes, thereby disabling the normal enzymatic activity of the enzyme when it becomes necessary in cold environments where sunlight is poor.  This was the key point I made in the Cold Thermogenesis 6 blog years ago. 

Nitrosylated ferrous iron is particularly stable, as the binding of the nitrosyl ligand to ferrous iron (Fe(II)) is very strong. Hemoglobin is a prominent example of a heme protein that may be modified by the NO free radical by both pathways: NO may attach directly to the heme in the nitrosylation reaction, and independently form S-nitrosothiols by S-nitrosation of the thiol moieties. There are other heme proteins you will soon learn about that refine this process even further.  

Hemoglobin absorbs light at 280 nm (UVC) and 3 other IR frequencies. Maybe now you can see why they link to NO function via the 42% red light in our sun.  The addition of sunlight and seasonal ketosis keeps the TCA and urea cycle clear of a lot of RNS and ROS from broken kinetics in both cycles due to a loss of control of hydrogen isoforms from cell membrane damage. 

The sun is designed to increase the mammalian battery using UV/IR light and cold for humans with bad environments.  The Quantlet was designed with this idea in mind.  The best idea is not to rely on any man made device, but to rely on sunlight with a seasonal ketosis regimen in humans to make metabolic cell water devoid of deuterium in the matrix.  Deuterium needs to be kept in the blood to make UV light in us endogenously that programs the proteins in us because it passes its information and energy to water that surrounds every protein in us.

 CITES:

Dr. Kruse talk June 2, 2018 Shelburne Farms.